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Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice

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dc.contributor.authorThompson, Dawn
dc.contributor.authorMahmood, Shehroz
dc.contributor.authorMorrice, Nicola
dc.contributor.authorKamli-Salino, Sarah
dc.contributor.authorDekeryte, Ruta
dc.contributor.authorHoffmann, Philip
dc.contributor.authorDoherty, Mary K
dc.contributor.authorWhitfield, Philip D.
dc.contributor.authorDelibegović, Mirela
dc.contributor.authorMody, Nimesh
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.date.accessioned2023-03-09T15:43:01Z
dc.date.available2023-03-09T15:43:01Z
dc.date.issued2023-03-09
dc.descriptionAcknowledgements This study was supported by funds from the British Heart Foundation (PG16/90/32518) project grant to N. Mody and a PhD studentship to S.M. by the James Mearns Trust and School of Medicine, Medical Sciences and Nutrition, University of Aberdeen (UoA). No potential conflicts of interest relevant to this article are reported. N. Mody and D.T. conceived the study, designed the experiments and wrote the manuscript. D.T., S.M, N. Morrice, R.D., S.K.S, P.H. performed experiments. P.W. and M.D. performed the ceramide analysis, M.D. contributed to the study conception, discussions and reviewed the manuscript. N.Mody is the guarantor of this work and, as such, had full access to all the data in this study and takes responsibility for the integrity and accuracy of the data analysis. The authors thank the UoA animal research facility, qPCR core facility (Institute of Medical Sciences, UoA) and Linda Davidson (NHS Grampian) for their technical contributions regarding animal studies, qPCR and histology respectively and Alison Rutter at UHI for lipidomics support. We thank UoA Masters students Emma Forbes and Nawaf Alsulami for assisting in experiments on ApoE-/- mice. The authors also wish to thank Patrick W F Hadoke (University of Edinburgh) and Heather M Wilson (UoA) for invaluable discussions about mechanisms of atherosclerosis and review of the manuscript, Matteo Zanda, Sergio Dall’Angelo, Chiara Zanato and Ilaria Patruno (all UoA) for medicinal chemistry support.en
dc.description.statusPeer revieweden
dc.format.extent2325766
dc.identifier228985183
dc.identifier32204714-127c-4003-b69d-3f7757f09d23
dc.identifier36894641
dc.identifier85149648102
dc.identifier.citationThompson, D, Mahmood, S, Morrice, N, Kamli-Salino, S, Dekeryte, R, Hoffmann, P, Doherty, M K, Whitfield, P D, Delibegović, M & Mody, N 2023, 'Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice', Scientific Reports, vol. 13, 3937. https://doi.org/10.1101/2022.07.22.500933, https://doi.org/10.1038/s41598-023-30759-wen
dc.identifier.doi10.1101/2022.07.22.500933
dc.identifier.issn2045-2322
dc.identifier.otherbiorxiv: 197808
dc.identifier.otherORCID: /0000-0002-2215-7952/work/147568304
dc.identifier.otherORCID: /0000-0002-5107-5366/work/160390076
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847584
dc.identifier.otherORCID: /0000-0003-0948-9458/work/162725699
dc.identifier.urihttps://hdl.handle.net/2164/20263
dc.identifier.urlhttps://www.researchsquare.com/article/rs-2183793/v1en
dc.identifier.vol13en
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectPG16/90/32518en
dc.subject.lccRen
dc.titleFenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- miceen
dc.typeJournal articleen

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