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Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

dc.contributor.authorStappers, Mark H T
dc.contributor.authorClark, Alexandra E
dc.contributor.authorAimanianda, Vishukumar
dc.contributor.authorBidula, Stefan
dc.contributor.authorReid, Delyth M
dc.contributor.authorAsamaphan, Patawee
dc.contributor.authorHardison, Sarah E
dc.contributor.authorDambuza, Ivy M
dc.contributor.authorValsecchi, Isabel
dc.contributor.authorKerscher, Bernhard
dc.contributor.authorPlato, Anthony
dc.contributor.authorWallace, Carol A
dc.contributor.authorYuecel, Raif
dc.contributor.authorHebecker, Betty
dc.contributor.authorda Glória Teixeira Sousa, Maria
dc.contributor.authorCunha, Cristina
dc.contributor.authorLiu, Yan
dc.contributor.authorFeizi, Ten
dc.contributor.authorBrakhage, Axel A
dc.contributor.authorKwon-Chung, Kyung J
dc.contributor.authorGow, Neil A R
dc.contributor.authorZanda, Matteo
dc.contributor.authorPiras, Monica
dc.contributor.authorZanato, Chiara
dc.contributor.authorJaeger, Martin
dc.contributor.authorNetea, Mihai G
dc.contributor.authorvan de Veerdonk, Frank L
dc.contributor.authorLacerda, João F
dc.contributor.authorCampos, António
dc.contributor.authorCarvalho, Agostinho
dc.contributor.authorWillment, Janet A
dc.contributor.authorLatgé, Jean-Paul
dc.contributor.authorBrown, Gordon D
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2018-08-28T23:03:15Z
dc.date.available2018-08-28T23:03:15Z
dc.date.embargoedUntil2018-08-28
dc.date.issued2018-03-15
dc.descriptionWe thank the staff of the University of Aberdeen animal facility for their support and care for our animals, C. G. Park for providing recombinant langerin, and S. Filler and R. Cramer for advice. Funding was provided by the Wellcome Trust (102705, 097377, 093378, 099197, 108430, 101873), the Medical Research Council Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). K.J.K.-C is supported by the intramural program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health; V.A. by an ANR-DST COMASPIN grant (ANR-13-ISV3-0004); B.H. by German Science Foundation (www.dfg.de) grant no. HE 7565/1-1; J.-P.L., I.V. and V.A. by the ANR and FRM DEQ2015-331722; A.C. by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), and by the Fundação para a Ciência e Tecnologia (FCT) (IF/00735/2014 and SFRH/BPD/96176/2013).en
dc.description.statusPeer revieweden
dc.format.extent5
dc.format.extent234415
dc.format.extent8508
dc.format.extent309214
dc.format.extent1983839
dc.format.extent1078572
dc.format.extent147429
dc.format.extent64521
dc.format.extent24658
dc.identifier115631356
dc.identifier0b74d73f-1bf2-4f7a-a5f6-65d9bc52dcc4
dc.identifier29489751
dc.identifier000427477100039
dc.identifier85044198849
dc.identifier.citationStappers, M H T, Clark, A E, Aimanianda, V, Bidula, S, Reid, D M, Asamaphan, P, Hardison, S E, Dambuza, I M, Valsecchi, I, Kerscher, B, Plato, A, Wallace, C A, Yuecel, R, Hebecker, B, da Glória Teixeira Sousa, M, Cunha, C, Liu, Y, Feizi, T, Brakhage, A A, Kwon-Chung, K J, Gow, N A R, Zanda, M, Piras, M, Zanato, C, Jaeger, M, Netea, M G, van de Veerdonk, F L, Lacerda, J F, Campos, A, Carvalho, A, Willment, J A, Latgé, J-P & Brown, G D 2018, 'Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus', Nature, vol. 555, no. 7696, pp. 382-386. https://doi.org/10.1038/nature25974en
dc.identifier.doi10.1038/nature25974
dc.identifier.iss7696en
dc.identifier.issn0028-0836
dc.identifier.otherORCID: /0000-0002-7040-0857/work/59831264
dc.identifier.urihttp://hdl.handle.net/2164/10990
dc.identifier.vol555en
dc.language.isoeng
dc.relation.ispartofNatureen
dc.subjectfungal host responseen
dc.subjectpattern recognition receptorsen
dc.subjectQR180 Immunologyen
dc.subjectWellcome Trusten
dc.subject102705en
dc.subject097377en
dc.subject093378en
dc.subject099197en
dc.subject108430en
dc.subject101873en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subject.lccQR180en
dc.titleRecognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillusen
dc.typeJournal articleen

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