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Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival

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dc.contributor.authorPorter, Ross J.
dc.contributor.authorMurray, Graeme I.
dc.contributor.authorHapca, Sandra
dc.contributor.authorHay, Andrew
dc.contributor.authorCraig, Stephanie G.
dc.contributor.authorHumphries, Matthew P.
dc.contributor.authorJames, Jacqueline A.
dc.contributor.authorSalto-Tellez, Manuel
dc.contributor.authorBrice, Daniel P.
dc.contributor.authorBerry, Susan H.
dc.contributor.authorMcLean, Mairi H.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2023-03-28T10:58:01Z
dc.date.available2023-03-28T10:58:01Z
dc.date.issued2023-03-20
dc.descriptionAcknowledgments: The authors would like to thank NHS Grampian Biorepository, in particular Joan Wilson, Victoria Morrison, Kristine Nellany, and Nadine Hay, for their assistance in preparing tissue for this project. The authors also thank Tasneem O Atezia and Christina A Christopoulou for their contribution to this project during their time in the McLean laboratory. The laboratory work was instigated when M.H.M., R.J.P. and D.P.B. were based at the Institute of Medical Sciences, University of Aberdeen. Funding This work was funded by project grants from NHS Grampian Endowments and Friends of Anchor (https://www.friendsofanchor.org, charity no. SC025332). Within the McLean laboratory at the University of Aberdeen, SH received a Medical Research Scotland Summer Studentship, and AH received an Aberdeen Summer Research Studentship (University of Aberdeen).en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent2034086
dc.identifier232678931
dc.identifier91bca49a-832b-4405-9da1-a6de66f12b9b
dc.identifier85151473522
dc.identifier.citationPorter, R J, Murray, G I, Hapca, S, Hay, A, Craig, S G, Humphries, M P, James, J A, Salto-Tellez, M, Brice, D P, Berry, S H & McLean, M H 2023, 'Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival', Cancers, vol. 15, no. 6, 1865. https://doi.org/10.3390/cancers15061865en
dc.identifier.doi10.3390/cancers15061865
dc.identifier.iss6en
dc.identifier.issn2072-6694
dc.identifier.otherRIS: urn:DF06B7D774D057C687A3E0AF8B074F46
dc.identifier.urihttps://hdl.handle.net/2164/20353
dc.identifier.vol15en
dc.language.isoeng
dc.relation.ispartofCancersen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHMGB1en
dc.subjectcolorectal canceren
dc.subjectmismatch repairen
dc.subjectlymphocytesen
dc.subjectcytokineen
dc.subjecttherapyen
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleSubcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survivalen
dc.typeJournal articleen

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