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Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects

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dc.contributor.authorHendawy, O. M.
dc.contributor.authorGomaa, Hesham A.M.
dc.contributor.authorAlzarea, Sami I.
dc.contributor.authorAlshammari, Mutariah S.
dc.contributor.authorMohamed, Fatma A.M.
dc.contributor.authorMostafa, Yaser A.
dc.contributor.authorAbdelazeem, Ahmed H.
dc.contributor.authorAbdelrahman, Mostafa H.
dc.contributor.authorTrembleau, Laurent
dc.contributor.authorYoussif, Bahaa G.M.
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.date.accessioned2022-08-23T23:07:22Z
dc.date.available2022-08-23T23:07:22Z
dc.date.embargoedUntil2022-08-24
dc.date.issued2021-11-01
dc.descriptionFunding Information: The authors extend their appreciation to the Deanship of Scientific Research at Jouf University for funding this work through research grant number (DSR2020-04-421 )en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent1697097
dc.identifier200868606
dc.identifier7d1c98a9-938b-46c0-8aa9-d6a2141d72f1
dc.identifier85113795824
dc.identifier.citationHendawy, O M, Gomaa, H A M, Alzarea, S I, Alshammari, M S, Mohamed, F A M, Mostafa, Y A, Abdelazeem, A H, Abdelrahman, M H, Trembleau, L & Youssif, B G M 2021, 'Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects', Bioorganic Chemistry, vol. 116, 105302. https://doi.org/10.1016/j.bioorg.2021.105302en
dc.identifier.doi10.1016/j.bioorg.2021.105302
dc.identifier.issn0045-2068
dc.identifier.otherORCID: /0000-0001-6376-9077/work/100717603
dc.identifier.urihttps://hdl.handle.net/2164/19093
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85113795824&partnerID=8YFLogxKen
dc.identifier.vol116en
dc.language.isoeng
dc.relation.ispartofBioorganic Chemistryen
dc.subjectCardiomyopathyen
dc.subjectCOX-2/sEHen
dc.subjectNSAIDSen
dc.subjectPyrazolesen
dc.subjectQD Chemistryen
dc.subjectBiochemistryen
dc.subjectMolecular Biologyen
dc.subjectDrug Discoveryen
dc.subjectOrganic Chemistryen
dc.subjectSupplementary Dataen
dc.subjecthttps://doi. org/10.1016/j.bioorg.2021.105302en
dc.subject.lccQDen
dc.titleNovel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effectsen
dc.typeJournal articleen

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