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RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

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dc.contributor.authorSpence, Holly
dc.contributor.authorWaldron, Fergal
dc.contributor.authorSaleeb, Rebecca S
dc.contributor.authorBrown, Anna-Leigh
dc.contributor.authorRifai, Olivia M
dc.contributor.authorGilodi, Martina
dc.contributor.authorRead, Fiona
dc.contributor.authorNellany, Kristine
dc.contributor.authorMilne, Gillian
dc.contributor.authorWilkinson, Debbie
dc.contributor.authorO'shaughnessy, Judi
dc.contributor.authorPastore, Annalisa
dc.contributor.authorFratta, Pietro
dc.contributor.authorShneider, Neil
dc.contributor.authorTartaglia, Gian Gaetano
dc.contributor.authorZacco, Elsa
dc.contributor.authorHorrocks, Mathew H
dc.contributor.authorGregory, Jenna
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.date.accessioned2024-03-15T11:52:00Z
dc.date.available2024-03-15T11:52:00Z
dc.date.issued2024-06
dc.descriptionOpen Access via the Springer Agreement The research leading to this manuscript has been supported by (i) a Target ALS foundation grant to JMG, MHH, GGT, EZ and NS and employing MG and FMW BB-2022-C4-L2; (ii) an NIH grant to JG and MHH, employing HS and FR R01NS127186; (iii) the European Research Council (RIBOMYLOME_309545 and ASTRA_855923) to GGT; and (iv) an MND Association Lady Edith Wolfson Junior Non-Clinical Fellowship to RS Saleeb/Oct22/980-799 (RSS). The authors would also like to thank the University of Aberdeen Microscopy and Histology Core Facility in the Institute of Medical Sciences.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent16933792
dc.identifier284673348
dc.identifierb7c85c7c-a1b3-41f1-a4bf-f3c17774d581
dc.identifier85186594907
dc.identifier38443601
dc.identifier.citationSpence, H, Waldron, F, Saleeb, R S, Brown, A-L, Rifai, O M, Gilodi, M, Read, F, Nellany, K, Milne, G, Wilkinson, D, O'shaughnessy, J, Pastore, A, Fratta, P, Shneider, N, Tartaglia, G G, Zacco, E, Horrocks, M H & Gregory, J 2024, 'RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS', Acta Neuropathologica, vol. 147, 50. https://doi.org/10.1007/s00401-024-02705-1en
dc.identifier.doi10.1007/s00401-024-02705-1
dc.identifier.issn0001-6322
dc.identifier.otherORCID: /0000-0002-1628-6790/work/155729049
dc.identifier.otherORCID: /0000-0003-2622-0776/work/155729472
dc.identifier.otherORCID: /0000-0003-0237-3807/work/155729642
dc.identifier.otherORCID: /0000-0003-3337-4079/work/155730368
dc.identifier.otherORCID: /0000-0003-1153-2646/work/155730676
dc.identifier.urihttps://hdl.handle.net/2164/23029
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85186594907&partnerID=8YFLogxKen
dc.identifier.urlhttps://doi.org/10.1101/2023.10.24.563701en
dc.identifier.vol147en
dc.language.isoeng
dc.relation.ispartofActa Neuropathologicaen
dc.subjectAcademic.en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject2040 Health, Nutrition and Wellbeingen
dc.subjectAmyotrophic lateral sclerosisen
dc.subjectCognitionen
dc.subjectCryptic splicingen
dc.subjectLoss-of-functionen
dc.subjectNeuropathologyen
dc.subjectRNA aptameren
dc.subjectStathmin-2en
dc.subjectTDP-43en
dc.subjectHumansen
dc.subjectAntibodiesen
dc.subjectAmyotrophic Lateral Sclerosis/geneticsen
dc.subjectRNA Splicingen
dc.subjectAptamers, Nucleotideen
dc.subjectDNA-Binding Proteins/geneticsen
dc.subjectR Medicineen
dc.subjectClinical Neurologyen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectPathology and Forensic Medicineen
dc.subject.lccRen
dc.titleRNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALSen
dc.typeJournal articleen

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