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Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity

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dc.contributor.authorZheng, Qiantao
dc.contributor.authorLin, Jun
dc.contributor.authorHuang, Jiaojiao
dc.contributor.authorZhang, Hongyong
dc.contributor.authorZhang, Rui
dc.contributor.authorZhang, Xueying
dc.contributor.authorCao, Chunwei
dc.contributor.authorHambly, Catherine
dc.contributor.authorQin, Guosong
dc.contributor.authorYao, Jing
dc.contributor.authorSong, Ruigao
dc.contributor.authorJia, Qitao
dc.contributor.authorWang, Xiao
dc.contributor.authorLi, Yongshun
dc.contributor.authorZhang, Nan
dc.contributor.authorPiao, Zhengyu
dc.contributor.authorYe, Rongcai
dc.contributor.authorSpeakman, John R
dc.contributor.authorWang, Hongmei
dc.contributor.authorZhou, Qi
dc.contributor.authorWang, Yanfang
dc.contributor.authorJin, Wanzhu
dc.contributor.authorZhao, Jianguo
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Energetics Research Groupen
dc.contributor.institutionUniversity of Aberdeen.Environment and Food Securityen
dc.date.accessioned2018-04-23T23:02:51Z
dc.date.available2018-04-23T23:02:51Z
dc.date.embargoedUntil2018-04-23
dc.date.issued2017-10
dc.descriptionAcknowledgments We thank members of the J.Z., W.J., and Y.W. laboratories for helpful discussions; P. Chai, S. Liu, H. Tang, and C. Wei (Institute of High Energy Physics at the Chinese Academy of Sciences and Beijing Engineering Research Center of Radiographic Techniques and Equipment) for their help with the PET scan experiments and analysis; L. Yang (Institute of Genetics and Developmental Biology at the Chinese Academy of Sciences) for help in TEM analysis; and Peter Thomson (University of Aberdeen) for technical assistance with isotope analysis. This study was supported by the National Transgenic Project of China (Grant 2016ZX08009003-006-007), the Strategic Priority Research Programs of the Chinese Academy of Sciences (Grants XDA08010304 and XDB13030000), the National Natural Science Foundation of China (Grants 81671274 and 31272440), and the National Program on Key Basic Research Project (973 Program; Grant 2015CB943100). Y.W. was supported by the Elite Youth Program of the Chinese Academy of Agricultural Sciences (ASTIP-IAS05). This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1707853114/-/DCSupplemental.en
dc.description.statusPeer revieweden
dc.format.extent9
dc.format.extent2154032
dc.identifier110830821
dc.identifierc46ca588-eb15-4b5b-8682-b55b80266667
dc.identifier29078316
dc.identifier85033771998
dc.identifier.citationZheng, Q, Lin, J, Huang, J, Zhang, H, Zhang, R, Zhang, X, Cao, C, Hambly, C, Qin, G, Yao, J, Song, R, Jia, Q, Wang, X, Li, Y, Zhang, N, Piao, Z, Ye, R, Speakman, J R, Wang, H, Zhou, Q, Wang, Y, Jin, W & Zhao, J 2017, 'Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity', PNAS, vol. 114, no. 45, pp. E9474-E9482. https://doi.org/10.1073/pnas.1707853114en
dc.identifier.doi10.1073/pnas.1707853114
dc.identifier.iss45en
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/2164/10356
dc.identifier.urlhttp://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1707853114/-/DCSupplementalen
dc.identifier.vol114en
dc.language.isoeng
dc.relation.ispartofPNASen
dc.subjectSDG 2 - Zero Hungeren
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectJournal Articleen
dc.subjectUCP1en
dc.subjectthermoregulationen
dc.subjectfat depositionen
dc.subjectpigen
dc.subjectCRISPR/Cas9en
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleReconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacityen
dc.typeJournal articleen

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