University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Experiences of running a stratified medicine adaptive platform trial : Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer

Simple item page
dc.contributor.authorFOCUS4 Trial Investigators
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2022-12-19T10:27:02Z
dc.date.available2022-12-19T10:27:02Z
dc.date.issued2022-04-01
dc.descriptionFunding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: FOCUS4 was co-funded by the Medical Research Council (MRC)/National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme and Cancer Research UK (CRUK) in April 2013. A subsequent AstraZeneca educational grant in 2017 funded the translational aspects of FOCUS4-C. Supply and distribution of AZD8931 for FOCUS-D and AZD1775 for FOCUS4-C were provided by AstraZeneca Ltd. Supply and distribution of aspirin and placebo for FOCUS4-B were provided by Bayer. The MRC Clinical Trials Unit at UCL receives core funding from the MRC within UK Research and Innovation (UKRI) (Budget: MC_UU_12023/20).en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent1080596
dc.identifier212441247
dc.identifierdc9eaf2a-bbcc-4fb8-baeb-cad53369e816
dc.identifier000751933300001
dc.identifier85124365121
dc.identifier.citationFOCUS4 Trial Investigators 2022, 'Experiences of running a stratified medicine adaptive platform trial : Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer', Clinical Trials, vol. 19, no. 2, pp. 146-157. https://doi.org/10.1177/17407745211069879en
dc.identifier.doi10.1177/17407745211069879
dc.identifier.iss2en
dc.identifier.issn1740-7745
dc.identifier.otherRIS: urn:C98A67A9776A8D9632D418E08FCEDB42
dc.identifier.otherORCID: /0000-0002-8402-8670/work/107489650
dc.identifier.urihttps://hdl.handle.net/2164/19747
dc.identifier.vol19en
dc.language.isoeng
dc.relation.ispartofClinical Trialsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectMetastaticen
dc.subjectcolorectal canceren
dc.subjectbiomarkeren
dc.subjectstratifieden
dc.subjectclinical trialen
dc.subjectmulti-arm multi-stageen
dc.subjectadaptiveen
dc.subjectcomplex innovative designen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_12023/20en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectCancer Research UKen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleExperiences of running a stratified medicine adaptive platform trial : Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal canceren
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Brown_etal_CT_Experiences_Of_Running_VoR.pdf
Size:
1.03 MB
Format:
Adobe Portable Document Format
Download

Collections

All research

The Sir Duncan Rice Library

University of Aberdeen

Bedford Road

Aberdeen

AB24 3AA


Tel: +44 (0)1224 273330

Email: library@abdn.ac.uk

Share and keep up to date


FacebookTwitterWordpress