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ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris : a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

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dc.contributor.authorWasi, Mohd
dc.contributor.authorKhandelwal, Nitesh K.
dc.contributor.authorMoorhouse, Alexander J.
dc.contributor.authorNair, Remya
dc.contributor.authorVishwakarma, Poonam
dc.contributor.authorRuiz, Gustavo B.
dc.contributor.authorRoss, Zoe K.
dc.contributor.authorLorenz, Alexander
dc.contributor.authorRudramurthy, Shivaprakash M.
dc.contributor.authorChakrabarti, Arunaloke
dc.contributor.authorLynn, Andrew M.
dc.contributor.authorMondal, Alok K.
dc.contributor.authorGow, Neil A. R.
dc.contributor.authorPrasad, Rajendra
dc.contributor.institutionUniversity of Aberdeen.Centre for Genome-Enabled Biology and Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2019-07-16T13:10:07Z
dc.date.available2019-07-16T13:10:07Z
dc.date.issued2019-07-16
dc.descriptionFunding This work was supported by the ICMR (AMR/149/2018-ECD-II) and DBT (BT/PR14117/BRB/10/1420/2015) to RP. AKM appreciates the support by research grant EMR/2016/001927 and DST PURSE II from the Department of Science and Technology (IN). MW was grateful for a Senior Research Fellowship from the University Grant Commission. NG acknowledges the Wellcome Trust support of a Senior Investigator (101873/Z/13/Z), Collaborative (200208/A/15/Z), and Strategic Awards (097377/Z11/Z), and the MRC Centre for Medical Mycology (MR/N006364/1). AJM was supported by the University of Aberdeen studentship. Work in AL’s laboratory was supported by the Wellcome Trust (212524/Z/18/Z) and the Medical Research Council (MRC) Centre for Medical Mycology at the University of Aberdeen (MR/P501955/1 and MR/N006364/1). Acknowledgments We thank the Centre for Genome Enabled Biology and Medicine at the University of Aberdeen (E. Collie-Duguid and S. Shaw) for sequencing and support with genome analysis.en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent8446711
dc.identifier144948535
dc.identifier9adf45df-1143-4fde-9714-1baef5d5be81
dc.identifier85069436412
dc.identifier000475791800001
dc.identifier31379756
dc.identifier.citationWasi, M, Khandelwal, N K, Moorhouse, A J, Nair, R, Vishwakarma, P, Ruiz, G B, Ross, Z K, Lorenz, A, Rudramurthy, S M, Chakrabarti, A, Lynn, A M, Mondal, A K, Gow, N A R & Prasad, R 2019, 'ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris : a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes', Frontiers in Microbiology, vol. 10, 1445. https://doi.org/10.3389/fmicb.2019.01445en
dc.identifier.doi10.3389/fmicb.2019.01445
dc.identifier.issn1664-302X
dc.identifier.otherMendeley: 634932af-34b4-32db-b483-3cb96f1f5fba
dc.identifier.otherORCID: /0000-0003-1550-1126/work/61521425
dc.identifier.otherORCID: /0000-0003-1925-3713/work/59851526
dc.identifier.urihttp://hdl.handle.net/2164/12579
dc.identifier.urlhttp://www.mendeley.com/research/abc-transporter-genes-show-upregulated-expression-drug-resistant-clinical-isolates-icandida-aurisi-gen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85069436412&partnerID=8YFLogxKen
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fmicb.2019.01445/full#supplementary-materialen
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofFrontiers in Microbiologyen
dc.subjectCandida aurisen
dc.subjectMultidrug resistance (MDR)en
dc.subjectABC proteinsen
dc.subjectdrug efflux pumpsen
dc.subjectwhole genome sequencingen
dc.subjectDrug efflux pumpsen
dc.subjectFluconazoleen
dc.subjectMultidrug resistanceen
dc.subjectmultidrug resistanceen
dc.subjectGLABRATAen
dc.subjectMECHANISMen
dc.subjectMEMBRANEen
dc.subjectYEASTen
dc.subjectfluconazoleen
dc.subjectINVENTORYen
dc.subjectCLONINGen
dc.subjectALBICANSen
dc.subjectPROTEINSen
dc.subjectSTEROL UPTAKEen
dc.subjectYCF1Pen
dc.subjectQR Microbiologyen
dc.subjectMicrobiology (medical)en
dc.subjectMicrobiologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectMR/P501955/1en
dc.subjectWellcome Trusten
dc.subject101873/Z/13/Zen
dc.subject200208/A/15/Zen
dc.subject097377/Z11/Zen
dc.subject212524/Z/18/Zen
dc.subjectSupplementary Dataen
dc.subject.lccQRen
dc.titleABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris : a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genesen
dc.typeJournal articleen

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