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p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

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dc.contributor.authorKilgas, Susan
dc.contributor.authorSingh, Abhay Narayan
dc.contributor.authorPaillas, Salome
dc.contributor.authorThen, Chee Kin
dc.contributor.authorTorrecilla, Ignacio
dc.contributor.authorNicholson, Judith
dc.contributor.authorBrowning, Lisa
dc.contributor.authorVendrell, Iolanda
dc.contributor.authorKonietzny, Rebecca
dc.contributor.authorKessler, Benedikt M.
dc.contributor.authorKiltie, Anne E.
dc.contributor.authorRamadan, Kristijan
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2021-06-17T20:13:01Z
dc.date.available2021-06-17T20:13:01Z
dc.date.issued2021-05-25
dc.descriptionFunding Information: This work was funded by Cancer Research UK (CRUK) program grant C5255/A23755 to A.E.K. Medical Research Council UK (MRC) program grant MC_PC 12001/1 (MC_UU_00001/1) and Breast Cancer Now (Grant No. 2019DecPR1406) to K.R. S.K. was supported by the MRC Oxford Institute of Radiation Oncology (OIRO) CRUK studentship. We thank Dr. Sovan Sarkar (Department of Oncology, University of Oxford) for generously providing DR-GFP U2OS cells. We thank Diogo Dias (Ludwig Cancer Research Institute, University of Oxford) for his technical advice on HR and SSA assays and assistance with the analysis. We thank Dr. Lisa Folkes and Alix Hampson for the high-performance liquid chromatography (HPLC) analysis of CB-5083 concentration in tissue extracts from CD-1 nude mice bearing subcutaneous RT112 tumors. We also thank the Oxford Radcliffe Biobank for providing us with human tissue sections.en
dc.description.statusPeer revieweden
dc.format.extent25
dc.format.extent6020567
dc.identifier195022030
dc.identifier3e1606f8-efea-4a74-a7a9-bc8094121f2d
dc.identifier85106522028
dc.identifier34038735
dc.identifier.citationKilgas, S, Singh, A N, Paillas, S, Then, C K, Torrecilla, I, Nicholson, J, Browning, L, Vendrell, I, Konietzny, R, Kessler, B M, Kiltie, A E & Ramadan, K 2021, 'p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation', Cell Reports, vol. 35, no. 8, 109153. https://doi.org/10.1016/j.celrep.2021.109153en
dc.identifier.doi10.1016/j.celrep.2021.109153
dc.identifier.iss8en
dc.identifier.issn2211-1247
dc.identifier.otherORCID: /0000-0001-7208-2912/work/96970537
dc.identifier.urihttps://hdl.handle.net/2164/16687
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85106522028&partnerID=8YFLogxKen
dc.identifier.vol35en
dc.language.isoeng
dc.relation.ispartofCell Reportsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectbladder canceren
dc.subjectCB-5083en
dc.subjectDNA damageen
dc.subjectDNA double-strand break repairen
dc.subjecthomologous recombinationen
dc.subjectionizing radiationen
dc.subjectIRen
dc.subjectMRE11en
dc.subjectp97en
dc.subjectsingle-strand annealingen
dc.subjectR Medicineen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectCancer Research UKen
dc.subjectC5255/A23755en
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_PC 12001/1en
dc.subjectOtheren
dc.subject.lccRen
dc.titlep97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiationen
dc.typeJournal articleen

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