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Phosphorylation by GRK5 regulates endocytosis of FPR2 independent of β-Arrestins

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dc.contributor.authorJack, Christine Elizabeth
dc.contributor.authorCope, Emily M
dc.contributor.authorLemel , Laura
dc.contributor.authorCanals, Meritxell
dc.contributor.authorDrube, Julia
dc.contributor.authorHoffmann, Carsten
dc.contributor.authorInoue , Asuka
dc.contributor.authorHislop, James
dc.contributor.authorThompson, Dawn
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2025-02-27T11:10:01Z
dc.date.available2025-02-27T11:10:01Z
dc.date.issued2025-02
dc.descriptionWe thank Kevin Pfleger, Rey Carabeo, Nevin Lambert and Mark von Zastrow for constructs and Aylin Hanyaloglu for sending cell lines. The authors acknowledge the Iain Fraser Cytometry Centre (RRID: SCR_022315) and the Microscopy and Histology Core Facility, University of Aberdeen for assistance in this work. CRediT authorship contribution statement Christine E. Jack: Writing – review & editing, Investigation, Formal analysis. Emily M. Cope: Writing – review & editing, Investigation, Formal analysis. Laura Lemel: Investigation. Meritxell Canals: Writing – review & editing, Supervision, Investigation. Julia Drube: Writing – review & editing, Resources, Methodology. Carsten Hoffmann: Writing – review & editing, Resources, Methodology. Asuka Inoue: Writing – review & editing, Resources. James N. Hislop: Writing – review & editing, Visualization, Validation, Supervision, Resources, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Conceptualization. Dawn Thompson: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Resources, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Conceptualization.en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent3528656
dc.identifier290720628
dc.identifierc30fecf5-f774-48e1-b196-ef90d9c93415
dc.identifier85214560642
dc.identifier85214560642
dc.identifier.citationJack, C E, Cope, E M, Lemel , L, Canals, M, Drube, J, Hoffmann, C, Inoue , A, Hislop, J & Thompson, D 2025, 'Phosphorylation by GRK5 regulates endocytosis of FPR2 independent of β-Arrestins', The Journal of Biological Chemistry, vol. 301, no. 2, 108112. https://doi.org/10.1016/j.jbc.2024.108112en
dc.identifier.doi10.1016/j.jbc.2024.108112
dc.identifier.iss2en
dc.identifier.issn0021-9258
dc.identifier.otherORCID: /0000-0003-0948-9458/work/175112530
dc.identifier.urihttps://hdl.handle.net/2164/25101
dc.identifier.vol301en
dc.language.isoeng
dc.relation.ispartofThe Journal of Biological Chemistryen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectGPCRen
dc.subjectFPR2en
dc.subjectGRKen
dc.subjectarrestinen
dc.subjectsignalingen
dc.subjecttraffickingen
dc.subjectR Medicineen
dc.subject.lccRen
dc.titlePhosphorylation by GRK5 regulates endocytosis of FPR2 independent of β-Arrestinsen
dc.typeJournal articleen

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