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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation : the BICS RCT

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dc.contributor.authorDevereux, Graham
dc.contributor.authorCotton, Seonaidh
dc.contributor.authorNath, Mintu
dc.contributor.authorMcMeekin, Nicola
dc.contributor.authorCampbell, Karen
dc.contributor.authorChaudhuri, Rekha
dc.contributor.authorChoudhury, Gourab
dc.contributor.authorDe Soyza, Anthony
dc.contributor.authorFielding, Shona
dc.contributor.authorGompertz, Simon
dc.contributor.authorHaughney, John
dc.contributor.authorLee, Amanda
dc.contributor.authorMacLennan, Graeme
dc.contributor.authorMorice, Alyn
dc.contributor.authorNorrie, John
dc.contributor.authorPrice, David
dc.contributor.authorShort, Philip
dc.contributor.authorVestbo, Jorgen
dc.contributor.authorWalker, Paul
dc.contributor.authorWedzicha, Jadwiga
dc.contributor.authorWilson, Andrew
dc.contributor.authorWu, Olivia
dc.contributor.authorLipworth, Brian
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Centre for Healthcare Randomised Trials (CHaRT)en
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Medical Statisticsen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2025-05-16T10:24:01Z
dc.date.available2025-05-16T10:24:01Z
dc.date.issued2025-05
dc.descriptionWe would like to thank all the participants who took part in the trial. We are grateful to all the staff at recruitment sites who facilitated identification, recruitment and follow-up of study participants (listed below). We are also grateful to other general practices and organisations that acted as PICs for the trial. We could not have completed the trial without the ongoing support of local and primary care research networks: NHS Research Scotland Primary Care Network – Amanda Cardy, Samantha Holden, Tracy Ibbotson, Catriona Loots, Yvonne McIlvenna, Kim Stringer. NIHR CRN North East and North Cumbria – Jill Ducker, Laura Gebbie, Clare Graham, Gillian Johnson, Fiona McIntosh, Rachel Nixon, Beth Pickering, Norah Phipps, Laura Renwick, Cheryl Rigg, Bertie Rowell, Rebecca Russell, Nicky Todd, Lauren Tough, Jacqui Vicars, Lisa Westwood, Alicja Yilmaz. NIHR CRN North West – Margaret Brunton, Lisa Cheng, Debbie Dickerson, Jacqui Dooley, Grace Hull, Kate Maitland, Julie Mugarza, Gail Timcke, Sara Yearsley. NIHR CRN South West Peninsula – Lynsey Beall, Tania Crabb, Samantha Hayward, Sara McNamara, Lauren Merrin. NIHR CRN East of England – Anneka Bicknell, Siobhan Campbell, Donna Clements, Kate Ellerby, Zenzi Fernandes, Julia Fromings Hill, Rachel Hollis, Bonnie Jackson, Emma Jameson, Jenny Johnson, Helen Jung, Heather Leishman, Philippa Lincoln, Suzanne Lockwood, Gosia Majsak-Newman, Kate McCloskey, Ruth Osborne, Julie Selley, Susanne Skinner, Karen Tibbenham, Nicola Ward, Gilda Watson. NIHR CRN East Midlands – Kylie Bate, Craig Beecroft, Michelle Chalke, John Cvancara, Kate Ellis, Fenglin Guo, Juliet Jones, Valentina Lazarevic, Hayley Simpson, Johanna Williams. NIHR CRN Kent, Surrey and Sussex – Natalie Billington, Claire Cox, Christina Gibbon, Louise Phillips. We are grateful to Janice Cruden for her secretarial and data co-ordination support and to other members of the CHaRT trial management and data co-ordination team for their help with discrete tasks. We are grateful to Kirsty McCormack for her help and advice in developing the grant proposal. We thank Mark Forrest and the programming team in CHaRT for developing and maintaining the trial website. We also thank Juliette Snow and Rachel West for their help with contracting, and Blair Annandale and Anne Buckle for their help in managing the budget. We are grateful for the guidance and support of the TSC (chairperson: Professor Edwin Chilvers; independent members: Matt Sydes, Rod Lawson, Dave Bertin and Alister Laird) and the DMC (chairperson: Mike Thomas; independent members: Michael Steiner, Stephen Gerry). The Health Services Research Unit is core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorate.en
dc.description.statusPeer revieweden
dc.format.extent114
dc.format.extent2302914
dc.identifier303947231
dc.identifier5d4de372-43c3-4db3-a133-945712325160
dc.identifier105005823126
dc.identifier40386836
dc.identifier.citationDevereux, G, Cotton, S, Nath, M, McMeekin, N, Campbell, K, Chaudhuri, R, Choudhury, G, De Soyza, A, Fielding, S, Gompertz, S, Haughney, J, Lee, A, MacLennan, G, Morice, A, Norrie, J, Price, D, Short, P, Vestbo, J, Walker, P, Wedzicha, J, Wilson, A, Wu, O & Lipworth, B 2025, 'Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation : the BICS RCT', Health Technology Assessment, vol. 29, no. 17, pp. i-xvi, 1-97. https://doi.org/10.3310/TNDG8641en
dc.identifier.doi10.3310/TNDG8641
dc.identifier.iss17en
dc.identifier.issn1366-5278
dc.identifier.otherRIS: urn:DCE050037EA3D9A2E308C256EAA40617
dc.identifier.otherORCID: /0000-0002-1039-5646/work/184350226
dc.identifier.otherORCID: /0000-0002-4865-9061/work/184350345
dc.identifier.otherORCID: /0000-0002-0753-0464/work/184350612
dc.identifier.urihttps://hdl.handle.net/2164/25468
dc.identifier.vol29en
dc.language.isoeng
dc.relation.ispartofHealth Technology Assessmenten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicine (General)en
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subject.lccR1en
dc.titleBisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation : the BICS RCTen
dc.typeJournal articleen

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