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Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

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dc.contributor.authorTyagi, Rahul
dc.contributor.authorMaddirala, Amarendar Reddy
dc.contributor.authorElfawal, Mostafa
dc.contributor.authorFischer, Chelsea
dc.contributor.authorBulman , Christina A.
dc.contributor.authorRosa, Bruce A.
dc.contributor.authorGao, Xin
dc.contributor.authorChugani, Ryan
dc.contributor.authorZhou, Mingzhou
dc.contributor.authorHelander, Jon
dc.contributor.authorBrindley, Paul J
dc.contributor.authorTseng, Chih-Chung
dc.contributor.authorGreig, Iain R
dc.contributor.authorSakanari, Judy
dc.contributor.authorWildman, Scott A.
dc.contributor.authorAroian, Raffi
dc.contributor.authorJanetka, James W.
dc.contributor.authorMitreva, Makedonka
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2019-05-01T23:02:20Z
dc.date.available2019-05-01T23:02:20Z
dc.date.embargoedUntil2019-05-02
dc.date.issued2018-07-13
dc.descriptionWe thank Qi Wang for her technical assistance related to clustering compounds and identifying representatives for screening. This work was supported by National Institute of Allergy and Infectious Diseases (NIAID) grant AI081803 to M.M. The study was also partly supported by NIAID grant AI056189 to R.V.A.en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent2253282
dc.identifier118756148
dc.identifier2ac11242-89b9-4115-a35c-3d3e23bb6db4
dc.identifier85046685547
dc.identifier.citationTyagi, R, Maddirala, A R, Elfawal, M, Fischer, C, Bulman , C A, Rosa, B A, Gao, X, Chugani, R, Zhou, M, Helander, J, Brindley, P J, Tseng, C-C, Greig, I R, Sakanari, J, Wildman, S A, Aroian, R, Janetka, J W & Mitreva, M 2018, 'Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics', ACS Infectious Diseases, vol. 4, no. 7, pp. 1130–1145. https://doi.org/10.1021/acsinfecdis.8b00090en
dc.identifier.doi10.1021/acsinfecdis.8b00090
dc.identifier.iss7en
dc.identifier.issn2373-8227
dc.identifier.otherORCID: /0000-0003-0338-8664/work/48201812
dc.identifier.otherORCID: /0000-0003-0603-3383/work/65549938
dc.identifier.urihttp://hdl.handle.net/2164/12228
dc.identifier.vol4en
dc.language.isoeng
dc.relation.ispartofACS Infectious Diseasesen
dc.subjectParasitic nematodesen
dc.subjecthookwormen
dc.subjectwhipwormen
dc.subjectfilarial nematodeen
dc.subjectwhole worm assayen
dc.subjectin vitroen
dc.subjectin vivoen
dc.subjecttarget class repurposingen
dc.subjectcarnitine palmitoyltransferase (CPT)en
dc.subjectbioaccumulationen
dc.subjectanthelminticen
dc.subjectR Medicine (General)en
dc.subject.lccR1en
dc.titleSmall Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelminticsen
dc.typeJournal articleen

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