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Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy

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dc.contributor.authorSommer, Nadine
dc.contributor.authorRoumane, Ahlima
dc.contributor.authorHan, Weiping
dc.contributor.authorDelibegović, Mirela
dc.contributor.authorRochford, Justin J.
dc.contributor.authorMcilroy, George D.
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2022-11-16T10:44:01Z
dc.date.available2022-11-16T10:44:01Z
dc.date.issued2022-12-08
dc.descriptionThe authors are extremely grateful to Dr Donna MacCallum (University of Aberdeen) for assistance with AAV vector i.v. tail vein injections and Pat Bain (University of Aberdeen) for design and generation of the graphical abstract. The authors would also like to thank the staff at the University of Aberdeen’s Microscopy and Histology Core Facility and the Medical Research Facility for support with animal breeding and maintenance. This research was supported by funding from the EFSD/Lilly Young Investigator Research Award Programme, Wellcome Trust ISSF Fellowship Support Fund, and Diabetes UK RD Lawrence Fellowship (21/0006280) awarded to G.D.M. and Diabetes UK (18/0005884) awarded to J.J.R.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1534353
dc.identifier219760367
dc.identifier9bac7a07-1602-4a1e-8da8-309dc8326e81
dc.identifier36320417
dc.identifier85140789614
dc.identifier.citationSommer, N, Roumane, A, Han, W, Delibegović, M, Rochford, J J & Mcilroy, G D 2022, 'Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy', Molecular Therapy - Methods & Clinical Development, vol. 27, pp. 206-216. https://doi.org/10.1016/j.omtm.2022.09.014en
dc.identifier.doi10.1016/j.omtm.2022.09.014
dc.identifier.issn2329-0501
dc.identifier.otherRIS: urn:7B72F1314D504E15A13414D7E8421CA7
dc.identifier.otherORCID: /0000-0003-4230-4355/work/120222791
dc.identifier.otherORCID: /0000-0002-5020-4939/work/120223086
dc.identifier.otherORCID: /0000-0003-2380-7117/work/156708555
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847629
dc.identifier.urihttps://hdl.handle.net/2164/19544
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S2329050122001395en
dc.language.isoeng
dc.relation.ispartofMolecular Therapy - Methods & Clinical Developmenten
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject204815/Z/16/Zen
dc.subject.lccRen
dc.titleGene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophyen
dc.typeJournal articleen

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