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Melatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

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dc.contributor.authorGalley, Helen F
dc.contributor.authorLowes, Damon A
dc.contributor.authorAllen, Lee
dc.contributor.authorCameron, Gary
dc.contributor.authorAucott, Lorna S
dc.contributor.authorWebster, Nigel R
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2014-05-02T10:02:01Z
dc.date.available2014-05-02T10:02:01Z
dc.date.issued2014-05
dc.descriptionThis article is protected by copyright. All rights reserved. This study was funded by the Chief Scientist Office, NHS Scotland. We would like to thank all the volunteers who gave up their time and blood to take part in the study and the data monitoring committee and staff of the intensive care unit for their support. In addition, thanks to Dr Malachy Columb for performing Page's trend test for us and to Annette Fearnley at Nu-Pharm Ltd for her advice.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent715407
dc.identifier32906263
dc.identifierb7712bc6-1c79-4f32-9c6a-72aac402fd93
dc.identifier24650045
dc.identifier84899429649
dc.identifier.citationGalley, H F, Lowes, D A, Allen, L, Cameron, G, Aucott, L S & Webster, N R 2014, 'Melatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis', Journal of Pineal Research, vol. 56, no. 4, pp. 427-438. https://doi.org/10.1111/jpi.12134en
dc.identifier.doi10.1111/jpi.12134
dc.identifier.iss4en
dc.identifier.issn0742-3098
dc.identifier.otherORCID: /0000-0001-6277-7972/work/84132258
dc.identifier.otherORCID: /0000-0002-3977-6733/work/159078581
dc.identifier.urihttp://hdl.handle.net/2164/3237
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=84897347874&partnerID=8YFLogxKen
dc.identifier.vol56en
dc.language.isoeng
dc.relation.ispartofJournal of Pineal Researchen
dc.subjectsepsisen
dc.subjectmelatoninen
dc.subject6-hydroxymelatoninen
dc.subjectphase 1 clinical trialen
dc.subjectcytokinesen
dc.subjectR Medicineen
dc.subjectChief Scientist Office (CSO)en
dc.subject.lccRen
dc.titleMelatonin as a potential therapy for sepsis : a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsisen
dc.typeJournal articleen

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