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The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors

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dc.contributor.authorThompson, Aiysha
dc.contributor.authorDavies, Luke C.
dc.contributor.authorLaio, Chia-Te
dc.contributor.authorda Fonseca, Diogo M.
dc.contributor.authorGriffiths, James S.
dc.contributor.authorAndrews, Robert
dc.contributor.authorJones, Adam V.
dc.contributor.authorClement, Mathew
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorHumphreys, Ian R.
dc.contributor.authorTaylor, Philip R.
dc.contributor.authorOrr, Selinda J.
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2019-07-02T10:40:11Z
dc.date.available2019-07-02T10:40:11Z
dc.date.issued2019-06-26
dc.descriptionAcknowledgments The authors wish to acknowledge the NIH-sponsored Mutant Mouse Regional Resource Center (MMRRC) National System as the source of genetically-altered mice (C57BL/6-Clec4etm1.1Cfg/Mmucd 031936-UCD) for use in this study. The mice were produced and deposited to the MMRRC by the Consortium for Functional Glycomics supported by the National Institute of General Medical Sciences (GM62116). We would like to thank Catherine Neiseryan and Ann Kift-Morgan for cell sorting. We would like to thank Wales Gene Park for providing computer resources that assisted this research. Funding: SJO was funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 099953/Z/12/Z) and by a Wellcome Trust ISSF Cross-Disciplinary Award. LCD is supported by a Henry Wellcome Trust Postdoctoral Fellowship (103973/Z/14/Z). CL is supported by a Kidney Research UK/MedImmune Joint Fellowship Award (PDF_006_20151127). GDB is funded by a Wellcome Trust Investigator Award (102705) and the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). IRH is supported by a Wellcome Trust Senior Research Fellowship (207503/Z/17/Z). PRT is supported by a Wellcome Trust Investigator Award (107964/Z/15/Z) and the UK Dementia Research Institute. Funding URLs: https://wellcome.ac.uk/ https://royalsociety.org/ https://www.kidneyresearchuk.org/ https://mrc.ukri.org/ https://ukdri.ac.uk/ The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data Availability: All relevant data apart from RNAseq files are within the manuscript and its Supporting Information files. RNAseq data files are available from ArrayExpress (https://www.ebi.ac.uk/arrayexpress/), (accession number E-MTAB-8030).en
dc.description.statusPeer revieweden
dc.format.extent29
dc.format.extent4250248
dc.identifier144312005
dc.identifier6e52d2e0-9eac-469c-98a6-9e41a9cf7f46
dc.identifier85068915474
dc.identifier31242262
dc.identifier000479154700041
dc.identifier.citationThompson, A, Davies, L C, Laio, C-T, da Fonseca, D M, Griffiths, J S, Andrews, R, Jones, A V, Clement, M, Brown, G D, Humphreys, I R, Taylor, P R & Orr, S J 2019, 'The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors', PLoS Pathogens, vol. 15, no. 6, e1007850. https://doi.org/10.1371/journal.ppat.1007850en
dc.identifier.doi10.1371/journal.ppat.1007850
dc.identifier.iss6en
dc.identifier.issn1553-7366
dc.identifier.otherMendeley: 1c16722a-b5ed-3c4e-98d8-fb48d6ceca8a
dc.identifier.urihttp://hdl.handle.net/2164/12477
dc.identifier.urlhttp://www.mendeley.com/research/protective-effect-inflammatory-monocytes-during-systemic-c-albicans-infection-dependent-collaboratioen
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85068915474&partnerID=8YFLogxKen
dc.identifier.vol15en
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHOST-DEFENSEen
dc.subjectDENDRITIC CELLSen
dc.subjectHUMAN DECTIN-1en
dc.subjectCANDIDAen
dc.subjectINDUCTIONen
dc.subjectPATHWAYen
dc.subjectPOLYMORPHISMen
dc.subjectRECOGNITIONen
dc.subjectRESPONSESen
dc.subjectMINCLEen
dc.subjectR Medicine (General)en
dc.subjectGeneticsen
dc.subjectMolecular Biologyen
dc.subjectVirologyen
dc.subjectParasitologyen
dc.subjectMicrobiologyen
dc.subjectImmunologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectOtheren
dc.subjectPDF_006_20151127en
dc.subjectWellcome Trusten
dc.subject099953/Z/12/Zen
dc.subject103973/Z/14/Zen
dc.subject102705en
dc.subject207503/Z/17/Zen
dc.subject107964/Z/15/Zen
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleThe protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptorsen
dc.typeJournal articleen

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