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NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia

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dc.contributor.authorHull, Claire
dc.contributor.authorDekeryte, Ruta
dc.contributor.authorBuchanan, Heather
dc.contributor.authorKamli-Salino, Sarah
dc.contributor.authorRobertson, Avril
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorPlatt, Bettina
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2021-09-11T23:06:01Z
dc.date.available2021-09-11T23:06:01Z
dc.date.issued2020-12-01
dc.descriptionAcknowledgments: This study was supported by ARUK project grant PG2017B-11 and ARUK summer scholarship funding from the Scottish ARUK network. The authors would like to thank Prof. Gernot Riedel for his support of the in vivo experimentation.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent3831324
dc.identifier175500450
dc.identifier97138cf8-7229-4caa-8611-6bccef142247
dc.identifier85091208330
dc.identifier32931815
dc.identifier85091208330
dc.identifier000593895300008
dc.identifier000593895300008
dc.identifier.citationHull, C, Dekeryte, R, Buchanan, H, Kamli-Salino, S, Robertson, A, Delibegovic, M & Platt, B 2020, 'NLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementia', Neuropharmacology, vol. 180, 108305. https://doi.org/10.1016/j.neuropharm.2020.108305, https://doi.org/10.1016/j.neuropharm.2020.108305en
dc.identifier.doi10.1016/j.neuropharm.2020.108305
dc.identifier.issn0028-3908
dc.identifier.otherORCID: /0000-0002-7852-0749/work/80463636
dc.identifier.otherORCID: /0000-0002-5107-5366/work/160390077
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847614
dc.identifier.urihttps://hdl.handle.net/2164/17054
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85091208330&partnerID=8YFLogxKen
dc.identifier.vol180en
dc.language.isoeng
dc.relation.ispartofNeuropharmacologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectTransgenicen
dc.subjectKnock-inen
dc.subjectDiabetesen
dc.subjectInsulinen
dc.subjectDementiaen
dc.subjectNLRP3en
dc.subjectInflammasomeen
dc.subjectER stressen
dc.subjectUPRen
dc.subjectInflammationen
dc.subjectR Medicineen
dc.subjectCellular and Molecular Neuroscienceen
dc.subjectPharmacologyen
dc.subjectArthritis Research UK (ARUK)en
dc.subjectPG2017B-11en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleNLRP3 inflammasome inhibition with MCC950 improves insulin sensitivity and inflammation in a mouse model of frontotemporal dementiaen
dc.typeJournal articleen

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