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In vitro Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties

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dc.contributor.authorAhmed, Suaad
dc.contributor.authorBusetti, Alessandro
dc.contributor.authorFotiadou, Parthena
dc.contributor.authorVincy Jose, Nisha
dc.contributor.authorReid, Sarah
dc.contributor.authorGeorgieva, Marieta
dc.contributor.authorBrown, Samantha
dc.contributor.authorDunbar, Hayley
dc.contributor.authorBeurket-Ascencio, Gloria
dc.contributor.authorDelday, Margaret I
dc.contributor.authorEttorre, Anna
dc.contributor.authorMulder, Imke E
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2019-11-01T15:05:01Z
dc.date.available2019-11-01T15:05:01Z
dc.date.issued2019-09-20
dc.descriptionAcknowledgments The authors are grateful to Dr. Nicole Reichardt and the 4D Pharma Isolation Team for their technical assistance with bacterial culture. Funding This work was privately funded by 4D Pharma PLC. The authors of the study, who are employees of (or in the case of MID, are funded by) 4D Pharma Research Ltd., a wholly owned subsidiary of the funder, were responsible for the design and execution of the study, as well as the analysis of the results obtained. Author Contributions In vitro experiments: AE, SA, and AB designed the experiments; SA, PF, NV, MG, SB, GB-A, and MD performed the majority of the in vitro experiments; SR, HD, and AB validated, performed, and analyzed the microbiological-related data output; AE coordinated and managed the research project; AE, SA, PF, and AB analyzed the data. IM oversaw the overall research plan. AE wrote the manuscript with the assistance of SA and AB. All authors have read and commented on the manuscript and have approved the final version of the manuscript. Data Availability: 16S gene sequences for MRx0005 and MRx0029 are disclosed in International Patent Publication Nos. WO2018/229189 and WO2018/229216, respectively, filed by 4D Pharma Research Ltd. The data supporting the findings in this paper are available within the article and its Supplementary Information Files.en
dc.description.statusPeer revieweden
dc.format.extent2554983
dc.identifier148963065
dc.identifierb1433f35-31a2-4b2f-bf7f-9bdecd97fcae
dc.identifier31619962
dc.identifier000487307600001
dc.identifier85073003892
dc.identifier.citationAhmed, S, Busetti, A, Fotiadou, P, Vincy Jose, N, Reid, S, Georgieva, M, Brown, S, Dunbar, H, Beurket-Ascencio, G, Delday, M I, Ettorre, A & Mulder, I E 2019, 'In vitro Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties', Frontiers in cellular neuroscience, vol. 13, 402. https://doi.org/10.3389/fncel.2019.00402en
dc.identifier.doi10.3389/fncel.2019.00402
dc.identifier.issn1662-5102
dc.identifier.otherPubMedCentral: PMC6763572
dc.identifier.urihttps://hdl.handle.net/2164/13208
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fncel.2019.00402/full#S10en
dc.identifier.vol13en
dc.language.isoeng
dc.relation.ispartofFrontiers in cellular neuroscienceen
dc.subjectgut microbiota-derived bacterial strainsen
dc.subjectmicrobiomeen
dc.subjectneurodegenerative diseasesen
dc.subjectneuroinflammationen
dc.subjectneuroprotectionen
dc.subjectoxidative stressen
dc.subjectgut-brain axisen
dc.subjectshort-chain fatty acidsen
dc.subjectcellsen
dc.subjectbrain axisen
dc.subjectinvolvementen
dc.subjectdisordersen
dc.subjectmodelen
dc.subjectgas-chromatographyen
dc.subjectdistasonisen
dc.subjectchain fatty-acidsen
dc.subjectstressen
dc.subjectParkinson's diseaseen
dc.subjectQH301 Biologyen
dc.subjectSupplementary Dataen
dc.subject.lccQH301en
dc.titleIn vitro Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Propertiesen
dc.typeJournal articleen

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