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The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis

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dc.contributor.authorDambuza, Ivy M
dc.contributor.authorDrake, Thomas
dc.contributor.authorChapuis, Ambre
dc.contributor.authorZhou, Xin
dc.contributor.authorCorreia, Joao
dc.contributor.authorTaylor-Smith, Leanne
dc.contributor.authorLegrave, Nathalie
dc.contributor.authorRasmussen, Tim
dc.contributor.authorFisher, Matthew C.
dc.contributor.authorBicanic, Tihana
dc.contributor.authorHarrison, Thomas S
dc.contributor.authorJaspars, Marcel
dc.contributor.authorMay, Robin C
dc.contributor.authorBrown, Gordon D
dc.contributor.authorYuecel, Raif
dc.contributor.authorMacCallum, Donna M
dc.contributor.authorBallou, Elizabeth
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2018-05-31T10:16:22Z
dc.date.available2018-05-31T10:16:22Z
dc.date.issued2018-05-18
dc.descriptionWe thank Prof Joseph Heitman and Prof Kirsten Nielsen for helpful discussions. We thank Dr Lukasz Kozubowski for feedback on the manuscript. We thank Prof Arturo Casadevall for the anti-capsule antibody 18B7. We are grateful to Drs Attila Bebes and Linda Duncan in the Iain Fraser Cytometry Centre (Aberdeen University), Delyth Reed, and Debbie Wilkinson, Lucinda Wight and Kevin MacKenzie in the Microscopy and Histology Core Facility (Aberdeen University) for their expert help with the cytometry and microscopy experiments. We are also grateful for the assistance of staff at the University of Aberdeen Medical Research Facility. Funding: ERB: This work was supported by the UK Biotechnology and Biological Research Council (http://www.bbsrc.ac.uk; BB/M014525/1). IMD: Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (wellcome.ac.uk; 097377). AC, DMM: UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (https://www.nc3rs.org.uk; NC/N002482/1). GDB: Wellcome Trust (wellcome.ac.uk; 102705). IMD, TD, AC, GDB, RY, and DMM: MRC Centre for Medical Mycology at the University of Aberdeen (https://www.mrc.ac.uk; www.abdn.ac.uk; MR/N006364/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent28
dc.format.extent13159504
dc.identifier117405025
dc.identifierb7ef672d-a97e-4c14-acf7-322e9d7d433a
dc.identifier29775474
dc.identifier85047970898
dc.identifier.citationDambuza, I M, Drake, T, Chapuis, A, Zhou, X, Correia, J, Taylor-Smith, L, Legrave, N, Rasmussen, T, Fisher, M C, Bicanic, T, Harrison, T S, Jaspars, M, May, R C, Brown, G D, Yuecel, R, MacCallum, D M & Ballou, E 2018, 'The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis', PLoS Pathogens, vol. 14, no. 5, e1006978. https://doi.org/10.1371/journal.ppat.1006978en
dc.identifier.doi10.1371/journal.ppat.1006978
dc.identifier.iss5en
dc.identifier.issn1553-7366
dc.identifier.otherORCID: /0000-0003-4833-0378/work/47631087
dc.identifier.otherORCID: /0000-0002-2426-6028/work/163664371
dc.identifier.urihttp://hdl.handle.net/2164/10513
dc.identifier.vol14en
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.subjectCryptococcus neoformansen
dc.subjectTitan cellen
dc.subjectPathogenesisen
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/M014525/1en
dc.subjectWellcome Trusten
dc.subject097377en
dc.subject102705en
dc.subjectNational Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3R's)en
dc.subjectNC/N002482/1en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleThe Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesisen
dc.typeJournal articleen

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