University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

TORC1 determines Fab1 lipid kinase function at signaling endosomes and vacuoles

Simple item page
dc.contributor.authorChen, Zilei
dc.contributor.authorCarpio Malia, Pedro
dc.contributor.authorHatakeyama, Riko
dc.contributor.authorNicastro, Raffaele
dc.contributor.authorHu, Zehan
dc.contributor.authorPéli-Gulli, MariePierre
dc.contributor.authorGao, Jieqiong
dc.contributor.authorNishimura, Taki
dc.contributor.authorEskes, Elja
dc.contributor.authorStefan, Christopher J.
dc.contributor.authorWinderickx, Joris
dc.contributor.authorDengje, Joern
dc.contributor.authorDe Virgilio, Claudio
dc.contributor.authorUngermann, Christian
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2021-02-21T21:54:01Z
dc.date.available2021-02-21T21:54:01Z
dc.date.issued2021-01-25
dc.descriptionAcknowledgments: We thank Lars Langemeyer for feedback, all members from the Ungermann lab for discussions, and Kathrin Auffarth, Angela Perz, and Malika Jaquenoud for expert technical assistance. This work was supported by the DFG (UN111/10-1 to C.U.), the Canton of Fribourg (to J.D. and C.D.V.), and the Swiss National Science Foundation (310030_166474/184671 to C.D.V. and 310030_184781 and 316030_177088 to J.D.). Z.C. received support from a travel stipend of the Boehringer Ingelheim Fonds. P.C.M. received additional support from the graduate program of the Collaborative Research Center 944 (SFB 944) and Department of Biology/Chemistry Osnabrück. E.E. received a fellowship of FWO Vlaanderen, Belgium (SB-FWO 1S06419N). Author Contributions: Z.C. and P.C.M. conducted all experiments on Fab1 localization and function; R.H. conducted experiments on development and analysis of the Sch91–183 probe; R.N., Z.H., M.-P.P.-G., and J.D. did the phosphorylation assays and analyses; and E.E. and J.W. conceived and performed the initial Sch9 mapping. T.N. and C.J.S. did the lipid analysis of the mutant alleles. J.G. analyzed microcopy data with Z.C. C.D.V. and C.U. conceived the study and wrote the manuscript with support of J.W.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent3465776
dc.identifier178058907
dc.identifier0decbd32-7964-41c6-ae63-fa4ff105d810
dc.identifier85096927307
dc.identifier.citationChen, Z, Carpio Malia, P, Hatakeyama, R, Nicastro, R, Hu, Z, Péli-Gulli, M, Gao, J, Nishimura, T, Eskes, E, Stefan, C J, Winderickx, J, Dengje, J, De Virgilio, C & Ungermann, C 2021, 'TORC1 determines Fab1 lipid kinase function at signaling endosomes and vacuoles', Current Biology, vol. 31, no. 2, pp. 297-309. https://doi.org/10.1016/j.cub.2020.10.026en
dc.identifier.doi10.1016/j.cub.2020.10.026
dc.identifier.iss2en
dc.identifier.issn0960-9822
dc.identifier.otherORCID: /0000-0002-3065-6639/work/90173302
dc.identifier.urihttps://hdl.handle.net/2164/15902
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85096927307&partnerID=8YFLogxKen
dc.identifier.vol31en
dc.language.isoeng
dc.relation.ispartofCurrent Biologyen
dc.subjectFab1en
dc.subjectTORC1en
dc.subjectlysosomeen
dc.subjectvacuoleen
dc.subjectphosphoinositideen
dc.subjectsignaling endosomeen
dc.subjectPI(3,5)P2en
dc.subjectlipid kinaseen
dc.subjectcellular signalingen
dc.subjectlate endosomeen
dc.subjectR Medicineen
dc.subjectGeneral Agricultural and Biological Sciencesen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectOtheren
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleTORC1 determines Fab1 lipid kinase function at signaling endosomes and vacuolesen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Chen_etal_TORC1_Determines_Fab1_VOR.pdf
Size:
3.31 MB
Format:
Adobe Portable Document Format
Download

Collections

All research

The Sir Duncan Rice Library

University of Aberdeen

Bedford Road

Aberdeen

AB24 3AA


Tel: +44 (0)1224 273330

Email: library@abdn.ac.uk

Share and keep up to date


FacebookTwitterWordpress