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An epigenome-wide association study of sex-specific chronological ageing

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dc.contributor.authorMcCartney, Daniel L.
dc.contributor.authorZhang, Futao
dc.contributor.authorHillary, Robert F.
dc.contributor.authorZhang, Qian
dc.contributor.authorStevenson, Anna J.
dc.contributor.authorWalker, Rosie M.
dc.contributor.authorBermingham, Mairead L.
dc.contributor.authorMorris, Stewart W.
dc.contributor.authorCampbell, Archie
dc.contributor.authorMurray, Alison D.
dc.contributor.authorWhalley, Heather C.
dc.contributor.authorPorteous, David J.
dc.contributor.authorEvans, Kathryn L.
dc.contributor.authorChandra, Tamir
dc.contributor.authorDeary, Ian J.
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorYang, Jian
dc.contributor.authorVisscher, Peter M.
dc.contributor.authorMcRae, Allan F.
dc.contributor.authorMarioni, Riccardo E.
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2020-01-09T11:50:01Z
dc.date.available2020-01-09T11:50:01Z
dc.date.issued2019-12-31
dc.descriptionAvailability of Data and Material According to the terms of consent for GS participants, access to individual-level data (omics and phenotypes) must be reviewed by the GS Access Committee. Applications should be made to access@generationscotland.org. Full summary statistics for the analyses presented are publicly available online at https://doi.org/10.7488/ds/2709. Funding GS received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). Genotyping and DNA methylation profiling of the GS samples was carried out by the Genetics Core Laboratory at the Clinical Research Facility, University of Edinburgh, Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” ([STRADL; Reference 104036/Z/14/Z]). DLM and REM are supported by Alzheimer’s Research UK major project grant ARUK-PG2017B-10. PMV and AFM are supported by the NHMRC Fellowship Scheme (1078037, 1078901, and 1083656). JY is supported by an ARC Future Fellowship (FT180100186). RFH and AJS are supported by funding from the Wellcome Trust 4-year PhD in Translational Neuroscience – training the next generation of basic neuroscientists to embrace clinical research [108890/Z/15/Z]. CH and TB are supported by an MRC University Unit Programme Grant MC_UU_00007/10 (QTL in Health and Disease). Acknowledgements We are grateful to all the families who took part, the general practitioners and the Scottish School of Primary Care for their help in recruiting them, and the whole GS team that includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, healthcare assistants, and nurses.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent2577331
dc.identifier149495647
dc.identifierf7b2731c-6a74-4ef6-bf90-a39fbd3d54c1
dc.identifier85077373539
dc.identifier.citationMcCartney, D L, Zhang, F, Hillary, R F, Zhang, Q, Stevenson, A J, Walker, R M, Bermingham, M L, Morris, S W, Campbell, A, Murray, A D, Whalley, H C, Porteous, D J, Evans, K L, Chandra, T, Deary, I J, McIntosh, A M, Yang, J, Visscher, P M, McRae, A F & Marioni, R E 2019, 'An epigenome-wide association study of sex-specific chronological ageing', Genome Medicine, vol. 12, 1. https://doi.org/10.1186/s13073-019-0693-z, https://doi.org/10.7488/ds/2709en
dc.identifier.doi10.1186/s13073-019-0693-z
dc.identifier.issn1756-994X
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976622
dc.identifier.urihttps://hdl.handle.net/2164/13485
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofGenome Medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectDNA methylationen
dc.subjectageingen
dc.subjectsexual dimorphismen
dc.subjectX-chromosomeen
dc.subjectGeneration Scotlanden
dc.subjectR Medicine (General)en
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_UU_00007/10en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectAlzheimers Research UKen
dc.subjectARUK-PG2017B-10en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleAn epigenome-wide association study of sex-specific chronological ageingen
dc.typeJournal articleen

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