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Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

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dc.contributor.authorSiemienowicz, Katarzyna J
dc.contributor.authorFurmanska, Klaudia
dc.contributor.authorFilis, Panagiotis
dc.contributor.authorTalia, Chiara
dc.contributor.authorThomas, Jennifer
dc.contributor.authorFowler , Paul A
dc.contributor.authorRae, Mick T
dc.contributor.authorColin Duncan, W.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2022-02-06T00:04:48Z
dc.date.available2022-02-06T00:04:48Z
dc.date.embargoedUntil2022-02-06
dc.date.issued2021-04-05
dc.descriptionAcknowledgements The authors wish to acknowledge Joan Docherty, John Hogg, Marjorie Thomson, Peter Tennant and James Nixon and the staff at the Marshall Building, University of Edinburgh for their excellent animal husbandry. Dr Kirsten Hogg, Dr Fiona Connolly, Dr Junko Nio443 Kobayashi, Dr Avi Lerner and Lyndsey Boswell helped with tissue collection. Funding This work was funded by Medical Research Council (MRC) project grants (G0500717; G0801807; G0802782; MR/P011535/1) and supported by the MRC Centre for Reproductive Health (MR/N022556/1).en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent757880
dc.identifier186737015
dc.identifierdae28ad9-6a71-4d07-b795-0cddcbbf966e
dc.identifier85100622422
dc.identifier33556473
dc.identifier000626602900013
dc.identifier.citationSiemienowicz, K J, Furmanska, K, Filis, P, Talia, C, Thomas, J, Fowler , P A, Rae, M T & Colin Duncan, W 2021, 'Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome', Molecular and Cellular Endocrinology, vol. 525, 111196. https://doi.org/10.1016/j.mce.2021.111196en
dc.identifier.doi10.1016/j.mce.2021.111196
dc.identifier.issn0303-7207
dc.identifier.otherORCID: /0000-0002-4831-9075/work/90173080
dc.identifier.urihttps://hdl.handle.net/2164/18033
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85100622422&partnerID=8YFLogxKen
dc.identifier.vol525en
dc.language.isoeng
dc.relation.ispartofMolecular and Cellular Endocrinologyen
dc.subjectSubstantive connection via eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectpolycystic ovaries syndromeen
dc.subjectFibroblast Growth Factor 21 (FGF21)en
dc.subjectmetabolismen
dc.subjectprenatal programmingen
dc.subjectadrogensen
dc.subjectPolycystic ovary syndromeen
dc.subjectAndrogensen
dc.subjectFibroblast growth factor 21 (FGF21)en
dc.subjectPrenatal programmingen
dc.subjectMetabolismen
dc.subjectR Medicineen
dc.subjectEndocrinologyen
dc.subjectMolecular Biologyen
dc.subjectBiochemistryen
dc.subjectMedical Research Council (MRC)en
dc.subjectG0500717en
dc.subjectG0801807en
dc.subjectG0802782en
dc.subjectMR/P011535/1en
dc.subjectMR/N022556/1en
dc.subject.lccRen
dc.titlePubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndromeen
dc.typeJournal articleen

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