The molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels

McFarland, Matthew R.; Keller, Corina D.; Childers, Brandon M.; Adeniyi, Stephen A.; Corrigall, Holly; Raguin, Adélaïde; Romano, M. Carmen; Stansfield, Ian

The molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels

dc.contributor.author	McFarland, Matthew R.
dc.contributor.author	Keller, Corina D.
dc.contributor.author	Childers, Brandon M.
dc.contributor.author	Adeniyi, Stephen A.
dc.contributor.author	Corrigall, Holly
dc.contributor.author	Raguin, Adélaïde
dc.contributor.author	Romano, M. Carmen
dc.contributor.author	Stansfield, Ian
dc.contributor.institution	University of Aberdeen.Centre for Genome-Enabled Biology and Medicine	en
dc.contributor.institution	University of Aberdeen.East Bio	en
dc.contributor.institution	University of Aberdeen.Medicine, Medical Sciences & Nutrition	en
dc.contributor.institution	University of Aberdeen.Physics	en
dc.contributor.institution	University of Aberdeen.Medical Sciences	en
dc.contributor.institution	University of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB)	en
dc.date.accessioned	2019-08-29T09:00:07Z
dc.date.available	2019-08-29T09:00:07Z
dc.date.issued	2020-04-06
dc.description	Biotechnology and Biological Sciences Research Council (BBSRC) [BB/I020926/1 to I.S., BB/N017161/1 to I.S., M.C.R.]; BBSRC PhD studentship awards [M108703G, C103817D to I.S. and M.C.R.]. Funding for open access charge: Biotechnology and Biological Sciences Research Council.	en
dc.description.status	Peer reviewed	en
dc.format.extent	18
dc.format.extent	5641560
dc.format.extent	1395878
dc.identifier	155287598
dc.identifier	b4c17428-b3c5-42be-adf7-2eed8ab8fcdc
dc.identifier	32016368
dc.identifier	000525957500026
dc.identifier	85082561691
dc.identifier.citation	McFarland, M R, Keller, C D, Childers, B M, Adeniyi, S A, Corrigall, H, Raguin, A, Romano, M C & Stansfield, I 2020, 'The molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels', Nucleic Acids Research, vol. 48, no. 6, pp. 3071-3088. https://doi.org/10.1101/610790, https://doi.org/10.1093/nar/gkaa055	en
dc.identifier.doi	10.1101/610790
dc.identifier.iss	6	en
dc.identifier.issn	0305-1048
dc.identifier.other	ORCID: /0000-0002-7242-7906/work/59921156
dc.identifier.uri	http://hdl.handle.net/2164/12805
dc.identifier.url	http://www.scopus.com/inward/record.url?scp=85082561691&partnerID=8YFLogxK	en
dc.identifier.vol	48	en
dc.language.iso	eng
dc.relation.ispartof	Nucleic Acids Research	en
dc.subject	translation	en
dc.subject	tRNA synthetase	en
dc.subject	Saccharomyces cerevisiae	en
dc.subject	GCN4	en
dc.subject	Totally Asymmetric Simple Exclusion Process	en
dc.subject	FACTOR 2B COMPLEX	en
dc.subject	TRANSLATIONAL REGULATION	en
dc.subject	ESCHERICHIA-COLI	en
dc.subject	YEAST	en
dc.subject	MESSENGER-RNAS	en
dc.subject	IN-VIVO	en
dc.subject	GROWTH	en
dc.subject	GENOME-WIDE ANALYSIS	en
dc.subject	GENE-EXPRESSION	en
dc.subject	MUTATIONS	en
dc.subject	R Medicine (General)	en
dc.subject	Genetics	en
dc.subject	Biotechnology and Biological Sciences Research Council (BBSRC)	en
dc.subject	BB/I020926/1	en
dc.subject	BB/N017161/1	en
dc.subject	M108703G	en
dc.subject	C103817D	en
dc.subject	Supplementary Data	en
dc.subject.lcc	R1	en
dc.title	The molecular aetiology of tRNA synthetase depletion : induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels	en
dc.type	Journal article	en