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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

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dc.contributor.authorKoss, David J.
dc.contributor.authorJones, Glynn
dc.contributor.authorCranston, Anna
dc.contributor.authorGardner, Heidi
dc.contributor.authorKanaan, Nicholas M.
dc.contributor.authorPlatt, Bettina
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.date.accessioned2016-10-25T14:28:21Z
dc.date.available2016-10-25T14:28:21Z
dc.date.issued2016-12-01
dc.descriptionAcknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer’s and Care of the Elderly). Alz-50, CP13, MC-1 and PHF-1 antibodies were gifted from Dr. Peter Davies and brain lystates from BACE1−/−mice were obtained from Prof Mike Ashford. The work presented here was funded by Alzheimer’s Research UK (Grant refs: ARUKPPG2014A-21 and ARUK-NSG2015-1 to BP and DK and NIH/NIA grants NIH/NINDS R01 NS082730 and R01 AG044372 to NK)en
dc.description.statusPeer revieweden
dc.format.extent21
dc.format.extent2072065
dc.identifier71903039
dc.identifier455fb6e8-2d0f-47a9-a976-e483e5cafe68
dc.identifier84992070777
dc.identifier.citationKoss, D J, Jones, G, Cranston, A, Gardner, H, Kanaan, N M & Platt, B 2016, 'Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline', Acta Neuropathologica, vol. 132, no. 6, pp. 875–895. https://doi.org/10.1007/s00401-016-1632-3en
dc.identifier.doi10.1007/s00401-016-1632-3
dc.identifier.iss6en
dc.identifier.issn0001-6322
dc.identifier.otherORCID: /0000-0002-7852-0749/work/76976884
dc.identifier.otherORCID: /0000-0002-2796-6898/work/118192881
dc.identifier.urihttp://hdl.handle.net/2164/7589
dc.identifier.vol132en
dc.language.isoeng
dc.relation.ispartofActa Neuropathologicaen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAlzheimer’s diseaseen
dc.subjectamyloiden
dc.subjecttauen
dc.subjectcognitive declineen
dc.subjectdementiaen
dc.subjectpathologyen
dc.subjectR Medicineen
dc.subjectAlzheimers Research UKen
dc.subjectARUKPPG2014A-21en
dc.subjectARUK-NSG2015-1en
dc.subjectMedical Research Council (MRC)en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectR01 NS082730en
dc.subjectR01 AG044372en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleSoluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive declineen
dc.typeJournal articleen

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