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Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

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dc.contributor.authorPonnusamy, Suriyan
dc.contributor.authorCoss, Christopher C.
dc.contributor.authorThiyagarajan, Thirumagal
dc.contributor.authorWatts, Kate
dc.contributor.authorHwang, Dong-Jin
dc.contributor.authorHe, Yali
dc.contributor.authorSelth, Luke A.
dc.contributor.authorMcEwan, Iain J.
dc.contributor.authorDuke, Charles B.
dc.contributor.authorPagadala, Jayaprakash
dc.contributor.authorSingh, Geetika
dc.contributor.authorWake, Robert W.
dc.contributor.authorLedbetter, Christopher
dc.contributor.authorTilley, Wayne D.
dc.contributor.authorMoldoveanu, Tudor
dc.contributor.authorDalton, James T.
dc.contributor.authorMiller, Duane D.
dc.contributor.authorNarayanan, Ramesh
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2018-10-03T23:07:11Z
dc.date.available2018-10-03T23:07:11Z
dc.date.embargoedUntil2018-10-04
dc.date.issued2017-11
dc.descriptionAcknowledgements: The authors thank Mr. Maron Lee Barrett and Ms. Mayra Star for their technical help. The authors thank Dr. Dejian Ma for his technical help with the NMR studies. The authors thank the UTHSC and St. Jude NMR core for their help with the NMR studies. The authors thank Drs. Robert Getzenberg and Michael Mohler for providing useful comments on the manuscript. The authors thank Ms. Brandy Grimes for her help with tissue procurement. The authors thank Dr. Daniel Johnson of UT BioCore for microarray data analysis and Mr. Lorne Rose of UT-MRC core for microarray studies. Funding Source: The research presented in this manuscript was supported by a research funding provided by GTx, Inc. Memphis, TN to R. Narayanan and by a research funding provided by West Cancer Center to R. Narayanan.en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent7135320
dc.identifier109594030
dc.identifierf9c915a6-d7ad-4215-88c0-426764aa2a3f
dc.identifier85033771016
dc.identifier.citationPonnusamy, S, Coss, C C, Thiyagarajan, T, Watts, K, Hwang, D-J, He, Y, Selth, L A, McEwan, I J, Duke, C B, Pagadala, J, Singh, G, Wake, R W, Ledbetter, C, Tilley, W D, Moldoveanu, T, Dalton, J T, Miller, D D & Narayanan, R 2017, 'Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer', Cancer Research, vol. 77, no. 22, pp. 6282-6298. https://doi.org/10.1158/0008-5472.CAN-17-0976en
dc.identifier.doi10.1158/0008-5472.CAN-17-0976
dc.identifier.iss22en
dc.identifier.issn0008-5472
dc.identifier.urihttp://hdl.handle.net/2164/11216
dc.identifier.vol77en
dc.language.isoeng
dc.relation.ispartofCancer Researchen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAndrogen Receptor (AR)en
dc.subjectSelective Androgen Receptor Degraders (SARDs)en
dc.subjectAR Splice Variants (AR-SV)en
dc.subjectprostate canceren
dc.subjectCastration-Resistant Prostate Cancer (CRPC)en
dc.subjectAR antagonisten
dc.subjectAF-1-binding AR antagonisten
dc.subjectAR translocation inhibitoren
dc.subjectAR pan-antagonisten
dc.subjectR Medicine (General)en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleNovel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Canceren
dc.typeJournal articleen

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