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A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

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dc.contributor.authorWarren, Anne Y.
dc.contributor.authorMassie, Charlie E.
dc.contributor.authorWatt, Kate
dc.contributor.authorLuko, Katarina
dc.contributor.authorOrafidiya, Folake
dc.contributor.authorSelth, Luke A.
dc.contributor.authorMohammed, Hisham
dc.contributor.authorChohan, Brinder Singh
dc.contributor.authorMenon, Suraj
dc.contributor.authorBaridi, Ajoeb
dc.contributor.authorZhao, Wanfeng
dc.contributor.authorEscriu, Carlos
dc.contributor.authorD'Santos, Clive
dc.contributor.authorTaylor, Chris
dc.contributor.authorQureshi, Arham
dc.contributor.authorZecchini, Vincent R.
dc.contributor.authorShaw, Greg L.
dc.contributor.authorDehm, Scott M.
dc.contributor.authorMills, Ian G.
dc.contributor.authorCarroll, James S.
dc.contributor.authorTilley, Wayne D.
dc.contributor.authorMcEwan, Iain J.
dc.contributor.authorBaniahmad, Aria
dc.contributor.authorNeal, David E.
dc.contributor.authorAsim, Mohammad
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2018-09-24T15:10:07Z
dc.date.available2018-09-24T15:10:07Z
dc.date.issued2019-09
dc.descriptionWe acknowledge support from the National Cancer Research Institute (National Institute of Health Research (NIHR) collaborative study: “Prostate Cancer: Mechanism of Progression and Treatment (PROMPT)” (grant G0500966/75466). This work was funded by a Cancer Research UK program grant (to DEN) and funding from the US Department of Defense (Prostate Cancer Research Program Transformative Impact Award, grant ID W81XWH-13- 2-0093; WDT, SMD and LAS), National Health and medical Research Council (grant ID 1083961; LAS) and PCFA/Cancer Australia/Movember (grant IDs 1012337 and 1043482; WDT and LAS). The research programs of WDT and LAS are supported by the Movember Foundation and the Prostate Cancer Foundation of Australia through the Movember Revolutionary Team Award. This work was also supported by the National Institutes of Health (NIH) grant R01CA174777 to SMD. FO was supported by a PhD project grant from Prostate Cancer UK (S10-10). LAS and MA were supported by a Young Investigator Award from the Prostate Cancer Foundation of the USA.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent3240504
dc.identifier137897930
dc.identifier87bbf2d9-786c-46d6-80ee-9166a68bec87
dc.identifier85053771274
dc.identifier000458624900015
dc.identifier30237440
dc.identifier.citationWarren, A Y, Massie, C E, Watt, K, Luko, K, Orafidiya, F, Selth, L A, Mohammed, H, Chohan, B S, Menon, S, Baridi, A, Zhao, W, Escriu, C, D'Santos, C, Taylor, C, Qureshi, A, Zecchini, V R, Shaw, G L, Dehm, S M, Mills, I G, Carroll, J S, Tilley, W D, McEwan, I J, Baniahmad, A, Neal, D E & Asim, M 2019, 'A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer', Oncogene, vol. 38, no. 7, pp. 1136-1150. https://doi.org/10.1038/s41388-018-0501-zen
dc.identifier.doi10.1038/s41388-018-0501-z
dc.identifier.iss7en
dc.identifier.issn0950-9232
dc.identifier.otherMendeley: 07003e04-de88-3ce2-a344-e96fa777c25b
dc.identifier.urihttp://hdl.handle.net/2164/11167
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85053771274&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/reciprocal-feedback-between-pdz-binding-kinase-androgen-receptor-drives-prostate-canceren
dc.identifier.vol38en
dc.language.isoeng
dc.relation.ispartofOncogeneen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectprostate canceren
dc.subjectandrogen receptoren
dc.subjectsignalling kinaseen
dc.subjecttranscriptional regulationen
dc.subjectDOMAINen
dc.subjectORIGINATED PROTEIN-KINASEen
dc.subjectMITOTIC KINASEen
dc.subjectTOPKen
dc.subjectGENEen
dc.subjectANTIANDROGENen
dc.subjectRESISTANCEen
dc.subjectEXPRESSIONen
dc.subjectPBK/TOPKen
dc.subjectABIRATERONEen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectGeneticsen
dc.subjectMolecular Biologyen
dc.subjectCancer Researchen
dc.subjectCancer Research UKen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectG0500966/75466en
dc.subjectSupplementary Dataen
dc.subject.lccRC0254en
dc.titleA reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate canceren
dc.typeJournal articleen

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