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Systematic Gene Overexpression in Candida albicans identifies a Regulator of Early Adaptation to the Mammalian Gut

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dc.contributor.authorZnaidi, Sadri
dc.contributor.authorvan Wijlick, Lasse
dc.contributor.authorHernández-Cervantes, Arturo
dc.contributor.authorSertour, Natacha
dc.contributor.authorDesseyn, Jean‐Luc
dc.contributor.authorVincent, Frédéric
dc.contributor.authorAtanassova, Ralitsa
dc.contributor.authorGouyer, Valérie
dc.contributor.authorMunro, Carol A.
dc.contributor.authorBachellier-Bassi, Sophie
dc.contributor.authorDalle, Frédéric
dc.contributor.authorJouault, Thierry
dc.contributor.authorBougnoux, Marie-Elisabeth
dc.contributor.authord'Enfert, Christophe
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.date.accessioned2018-09-14T13:50:08Z
dc.date.available2018-09-14T13:50:08Z
dc.date.issued2018-11
dc.descriptionWe are grateful to members of the genomics core facility (PF2, Génopole) for the availability of the microarray scanner and the Alain Jacquier’s lab for making the GenePix software available. We are grateful to Drs. Suzanne Noble and Aaron Mitchell for providing C. albicans mutant collections. We thank all members of the Fungal Biology & Pathogenicity Unit, particularly Drs. Anne Neville and Adeline Feri for their numerous insights during the course of this project. This work has been supported by grants from the Agence Nationale de la Recherche (KANJI, ANR-08-MIE-033-01 to C.d’E. and F.D.; ERA-Net Infect-ERA, FUNCOMPATH, ANR-14-IFEC-0004; and CANDIHUB, ANR-14-CE-0018 to C.d’E.), the French Government’s Investissement d’Avenir program (Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases, ANR-10-LABX-62-IBEID to C.d’E.; Institut de Recherche Technologique BIOASTER, ANR-10-AIRT-03 to C.d’E., F.D. and T.J.), the European Commission (FinSysB PITN-GA-2008-214004 to C.d’E.) and the Wellcome Trust (The Candida albicans ORFeome project, WT088858MA to C.d’E. and C.M.). C.M. acknowledges support from the Medical Research Council, UK (New Investigator Award, G0400284), the MRC Centre for Medical Mycology (MR/N006364/1) and the University of Aberdeen. S.Z. is an Institut Pasteur International Network Affiliate Program Fellow. S.Z., L.v.W. and A.H.C. were the recipients of post-doctoral fellowships from the European Commission (FINSysB, PITN-GA-2008-214004 to S.Z.), the Agence Nationale de la Recherche (KANJI, ANR-08-MIE-033-01 to S.Z.; ERA-Net Infect-ERA, FUNCOMPATH, ANR-14-IFEC-0004 to A.H.C.; CANDIHUB, ANR-14-CE-0018 to L.v.W) and the French Government’s Investissement d’Avenir program (Institut de Recherche Technologique BIOASTER, ANR-10-AIRT-03 to S.Z. and A.H.C.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent1687724
dc.identifier129383828
dc.identifier7aafd480-b464-4716-a41b-a154a5c98b96
dc.identifier85052616625
dc.identifier.citationZnaidi, S, van Wijlick, L, Hernández-Cervantes, A, Sertour, N, Desseyn, JL, Vincent, F, Atanassova, R, Gouyer, V, Munro, C A, Bachellier-Bassi, S, Dalle, F, Jouault, T, Bougnoux, M-E & d'Enfert, C 2018, 'Systematic Gene Overexpression in Candida albicans identifies a Regulator of Early Adaptation to the Mammalian Gut', Cellular Microbiology, vol. 20, no. 11, 12890. https://doi.org/10.1111/cmi.12890en
dc.identifier.doi10.1111/cmi.12890
dc.identifier.iss11en
dc.identifier.issn1462-5814
dc.identifier.otherORCID: /0000-0003-0761-1755/work/162729019
dc.identifier.urihttp://hdl.handle.net/2164/11104
dc.identifier.vol20en
dc.language.isoeng
dc.relation.ispartofCellular Microbiologyen
dc.subjectCandida albicansen
dc.subjectgastrointestinal colonizationen
dc.subjectsignature-tagged overexpressionen
dc.subjecttranscriptomicsen
dc.subjectchromatin immunoprecipitation-on-chipen
dc.subjectregulatory networksen
dc.subjectCRZ2en
dc.subjectR Medicine (General)en
dc.subjectWellcome Trusten
dc.subjectWT088858MAen
dc.subjectEuropean Commissionen
dc.subjectFinSysB PITN-GA-2008-214004en
dc.subjectMedical Research Council (MRC)en
dc.subjectG0400284en
dc.subjectMR/N006364/1en
dc.subject.lccR1en
dc.titleSystematic Gene Overexpression in Candida albicans identifies a Regulator of Early Adaptation to the Mammalian Guten
dc.typeJournal articleen

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