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A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder

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dc.contributor.authorZeng, Yanni
dc.contributor.authorNavarro, Pau
dc.contributor.authorFernandez-Pujals, Ana M
dc.contributor.authorHall, Lynsey S
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorThomson, Pippa A
dc.contributor.authorSmith, Blair H
dc.contributor.authorHocking, Lynne J
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorHayward, Caroline
dc.contributor.authorMacIntyre, Donald J
dc.contributor.authorWray, Naomi R
dc.contributor.authorDeary, Ian J
dc.contributor.authorPorteous, David J
dc.contributor.authorHaley, Chris S
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2017-08-30T11:00:19Z
dc.date.available2017-08-30T11:00:19Z
dc.date.issued2017-02-15
dc.descriptionThis work was supported by the Wellcome Trust through a Strategic Award Reference No. 104036/Z/14/Z, the Dr. Mortimer and Theresa Sackler Foundation (T-KC and AMM), the Medical Research Council (MRC) to the Human Genetics Unit (PN and CSH), and the Biotechnology and Biological Sciences Research Council Grant No. BB/J004235/1 (PN and CSH). The Chief Scientist Office of the Scottish Government and the Scottish Funding Council provided core support for Generation Scotland (GS). GS: The Scottish Family Health Study (SFHS) was funded by a grant from the Scottish Government Health Department, Chief Scientist Office, No. CZD/16/6. This work was also supported by National Institutes of Health Grant No. UO1MH105630. We thank the families who took part in GS:SFHS, the general practitioners, and Scottish School of Primary Care for their help in recruiting them, and the whole GS team, which includes academic researchers, clinic staff, laboratory technicians, clerical workers, information technology staff, statisticians, and research managers. YZ thanks Mr. Ian White for the suggestion for analysis of polygenic score. AMF-P, LSH, BHS, LJH, SP, CH, and NRW report no biomedical financial interests or potential conflicts of interest. YZ received support from China Scholarship Council. PN and CSH received support from the MRC. T-KC and AMM received financial support for this work from the Dr. Mortimer and Theresa Sackler Foundation. PAT, IJD, DJP, and AMM are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1). DJM is an NRS (National Health Service Research Scotland) Fellow, funded by the Chief Scientist Office. AMM previously received grant support from Pfizer, Lilly, and Janssen; those studies are not connected to the present investigation.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent2184323
dc.identifier107336925
dc.identifier9d34dbf0-f13e-4eb7-836d-c0fe3508ce77
dc.identifier27422368
dc.identifier85002957330
dc.identifier.citationZeng, Y, Navarro, P, Fernandez-Pujals, A M, Hall, L S, Clarke, T-K, Thomson, P A, Smith, B H, Hocking, L J, Padmanabhan, S, Hayward, C, MacIntyre, D J, Wray, N R, Deary, I J, Porteous, D J, Haley, C S, McIntosh, A M & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2017, 'A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder', Biological Psychiatry, vol. 81, no. 4, pp. 336-346. https://doi.org/10.1016/j.biopsych.2016.04.017en
dc.identifier.doi10.1016/j.biopsych.2016.04.017
dc.identifier.iss4en
dc.identifier.issn0006-3223
dc.identifier.otherPubMedCentral: PMC5262437
dc.identifier.urihttp://hdl.handle.net/2164/9230
dc.identifier.vol81en
dc.language.isoeng
dc.relation.ispartofBiological Psychiatryen
dc.subjectDCCen
dc.subjectMDDen
dc.subjectNETRIN1en
dc.subjectPathway analysisen
dc.subjectPolygenic risk scoreen
dc.subjectRegional heritabilityen
dc.subjectJournal Articleen
dc.subjectQH426 Geneticsen
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/J004235/1en
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectScottish Funding Councilen
dc.subject.lccQH426en
dc.titleA Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorderen
dc.typeJournal articleen

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