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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

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dc.contributor.authorWinkler, Thomas W
dc.contributor.authorGrassmann, Felix
dc.contributor.authorBrandl, Caroline
dc.contributor.authorKiel, Christina
dc.contributor.authorGünther, Felix
dc.contributor.authorStrunz, Tobias
dc.contributor.authorWeidner, Lorraine
dc.contributor.authorZimmermann, Martina E
dc.contributor.authorKorb, Christina A
dc.contributor.authorPoplawski, Alicia
dc.contributor.authorSchuster, Alexander K
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorPeters, Annette
dc.contributor.authorRauscher, Franziska G
dc.contributor.authorElze, Tobias
dc.contributor.authorHorn, Katrin
dc.contributor.authorScholz, Markus
dc.contributor.authorCañadas-Garre, Marisa
dc.contributor.authorMcKnight, Amy Jayne
dc.contributor.authorQuinn, Nicola
dc.contributor.authorHogg, Ruth E
dc.contributor.authorKüchenhoff, Helmut
dc.contributor.authorHeid, Iris M
dc.contributor.authorStark, Klaus J
dc.contributor.authorWeber, Bernhard H F
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2020-09-07T13:40:01Z
dc.date.available2020-09-07T13:40:01Z
dc.date.issued2020-08-26
dc.descriptionFunding The AugUR study was supported by grants from the German Federal Ministry of Education and Research (BMBF 01ER1206, BMBF 01ER1507 to I.M.H.) and the University of Regensburg. The Gutenberg Health Study is funded through the government of Rhineland-Palatinate („Stiftung Rheinland-Pfalz für Innovation“, contract AZ 961-386261/733), the research programs “Wissenschafft Zukunft” and “Center for Translational Vascular Biology (CTVB)” of the Johannes Gutenberg-University of Mainz, and its contract with Boehringer Ingelheim and PHILIPS Medical Systems, including an unrestricted grant for the Gutenberg Health Study. Alexander K Schuster (A.K.S.) holds the professorship for ophthalmic healthcare research endowed by „Stiftung Auge “and financed by „Deutsche Ophthalmologische Gesellschaft “and „Berufsverband der Augenärzte Deutschland e.V.“. The International AMD Genomics Consortium (IAMDGC) is supported by a grant from NIH (R01 EY022310). Genotyping was supported by a contract (HHSN268201200008I) to the Center for Inherited Disease Research (http://amdgenetics.org/). In-depth analyses to estimate genetic effects in the IAMDGC data was supported by DFG HE 3690/5–1 to Iris M Heid (I.M.H.). The KORA study was initiated and financed by the Helmholtz Zentrum München – German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. Furthermore, KORA research was supported within the Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universität, as part of LMUinnovativ. This publication is supported by the Leipzig Research Centre for Civilization Diseases (LIFE), an organizational unit affiliated to the Medical Faculty of Leipzig University. LIFE is funded by means of the European Union, by the European Regional Development Fund (ERDF) and by funds of the Free State of Saxony within the framework of the excellence initiative (project numbers: 713–241202, 14505/2470, 14575/2470). Franziska G. Rauscher (F.G.R.) is supported by a grant from the German Federal Ministry of Education and Research: i:DSem - Integrative data semantics in systems medicine (031 L0026). Tobias Elze (T.E.) is funded by the Lions Foundation, Grimshaw-Gudewicz Foundation, Research to Prevent Blindness, BrightFocus Foundation, Alice Adler Fellowship, NEI R21EY030142,NEI R21EY030631, NEI R01EY030575, and NEI Core Grant P30EYE003790. The Atlantic Philanthropies, the Economic and Social Research Council, the UKCRC Centre of Excellence for Public Health Northern Ireland, the Centre for Ageing Research and Development in Ireland, the Office of the First Minister and Deputy First Minister, the Health and Social Care Research and Development Division of the Public Health Agency, the Wellcome Trust/Wolfson Foundation and Queen’s University Belfast provide core financial support for NICOLA. Marisa Cañadas-Garre (M.C.G.) is supported by Science Foundation Ireland and the Department for the Economy, Northern Ireland US partnership award (15/IA/3152). The molecular data employed for the NICOLAcohort were funded by Economic and Social Research Council (ES/L008459/1). The analyses were supported by German Research Foundation (DFG HE-3690/5–1 to I.M.H.) and by the National Institutes of Health (NIH R01 EY RES 511967 to I.M.H.). Felix Grassmann (F.G.) was a Leopoldina Postdoctoral Fellow (Grant No. LPDS 2018–06) funded by the Academy of Sciences Leopoldina. The position of Tobias Strunz (T.S.) is financed by the Helmut-Ecker-Foundation (# 05/17 to B.H.F.W.) and of Christina Kiel (C.K.) by a grant from the German Research Foundation to F.G. and B.H.F.W. (GR 5065/1–1). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. Open access funding provided by Projekt DEAL.en
dc.description.statusPeer revieweden
dc.format.extent18
dc.format.extent1311364
dc.identifier175426733
dc.identifier97637748-35e8-44f8-a30c-7fe60ac27ddd
dc.identifier32843070
dc.identifier85089930556
dc.identifier000566257800001
dc.identifier.citationWinkler, T W, Grassmann, F, Brandl, C, Kiel, C, Günther, F, Strunz, T, Weidner, L, Zimmermann, M E, Korb, C A, Poplawski, A, Schuster, A K, Müller-Nurasyid, M, Peters, A, Rauscher, F G, Elze, T, Horn, K, Scholz, M, Cañadas-Garre, M, McKnight, A J, Quinn, N, Hogg, R E, Küchenhoff, H, Heid, I M, Stark, K J & Weber, B H F 2020, 'Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease', BMC Medical Genomics, vol. 13, 120. https://doi.org/10.1186/s12920-020-00760-7en
dc.identifier.doi10.1186/s12920-020-00760-7
dc.identifier.issn1755-8794
dc.identifier.otherPubMedCentral: PMC7449002
dc.identifier.otherSCOPUS: 85089930556
dc.identifier.otherORCID: /0000-0003-1390-7528/work/80106769
dc.identifier.urihttps://hdl.handle.net/2164/15100
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85089930556&partnerID=8YFLogxKen
dc.identifier.urlhttps://abdn.elsevierpure.com/en/publications/97637748-35e8-44f8-a30c-7fe60ac27ddden
dc.identifier.vol13en
dc.language.isoeng
dc.relation.ispartofBMC Medical Genomicsen
dc.subjectGenome-wide association study (GWAS)en
dc.subjectMeta-analysisen
dc.subjectAge-related macular degeneration (AMD)en
dc.subjectEarly AMDen
dc.subjectCD46en
dc.subjectTYRen
dc.subjectInternational AMD genomics consortium (IAMDGC)en
dc.subjectUK Biobank (UKBB)en
dc.subjectMachine-learningen
dc.subjectAutomated phenotypingen
dc.subjectR Medicineen
dc.subjectGenetics(clinical)en
dc.subjectGeneticsen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleGenome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced diseaseen
dc.typeJournal articleen

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