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Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects

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dc.contributor.authorHan, Kim
dc.contributor.authorSingh, Komudi
dc.contributor.authorMeadows, Allison M
dc.contributor.authorSharma, Rahul
dc.contributor.authorHassanzadeh, Shahin
dc.contributor.authorWu, Jing
dc.contributor.authorGoss-Holmes, Haley
dc.contributor.authorHuffstutler, Rebecca D
dc.contributor.authorTeague, Heather L
dc.contributor.authorMehta, Nehal N
dc.contributor.authorGriffin, Julian L
dc.contributor.authorTian, Rong
dc.contributor.authorTraba, Javier
dc.contributor.authorSack, Michael N
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2023-10-03T11:28:02Z
dc.date.available2023-10-03T11:28:02Z
dc.date.issued2023-09-19
dc.descriptionAcknowledgments We thank Myron Waclawiw of the NHLBI Biostatistics Branch for assistance with the clinical protocol design, Chromadex for supplying NR and matching placebo capsules for the in vivo study and NR powder for the cell culture studies, and an NIH Bench-to-Bedside award for supplemental funding. We additionally thank Dr. Nina Klimova, formerly of the NHLBI, and Dr. Yun-Wei A. Hsu for their support of the metabolomics analysis at the Northwest Metabolomics Research Center of the University of Washington (NIH grant 1S10OD021562-01). We thank and acknowledge the assistance of the NHLBI DNA Sequencing and Genomics Core in performing the RNA library sequencing and Dr. Pradeep Dagur in the NHLBI Flow Cytometry Core for performing the immunophenotyping. Trial registration was as follows: ClinicalTrials.gov: NCT01934660, NCT02812238, and NCT01143454 and NIH Clinical Center blood bank (ClinicalTrials.gov: NCT00001846). This work was supported by the NHLBI Division of Intramural Research (ZIA-HL005102 to M.N.S.), NIH Bench-to-Bedside award (HL-129510-04S1 to M.N.S. and R.T.) and the NIH Office of Dietary Supplements (J.T.), the Spanish Ministry of Science and Innovation (RYC2018-026050-I and PID2019-105665RA-I00 to J.T.), and the UK MRC (MR/P011705/2 and UKDRI-5002 to J.L.G.; MAP UK).en
dc.description.statusPeer revieweden
dc.format.extent23
dc.format.extent7950006
dc.identifier281642466
dc.identifier56f95f7f-513e-4ec6-ac5c-0e9efb5ad558
dc.identifier37586364
dc.identifier85171170472
dc.identifier.citationHan, K, Singh, K, Meadows, A M, Sharma, R, Hassanzadeh, S, Wu, J, Goss-Holmes, H, Huffstutler, R D, Teague, H L, Mehta, N N, Griffin, J L, Tian, R, Traba, J & Sack, M N 2023, 'Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects', Cell reports. Medicine, vol. 4, no. 9, pp. 101157. https://doi.org/10.1016/j.xcrm.2023.101157en
dc.identifier.doi10.1016/j.xcrm.2023.101157
dc.identifier.iss9en
dc.identifier.issn2666-3791
dc.identifier.otherPubMedCentral: PMC10518596
dc.identifier.otherORCID: /0000-0003-1336-7744/work/144004086
dc.identifier.urihttps://hdl.handle.net/2164/21816
dc.identifier.vol4en
dc.language.isoeng
dc.relation.ispartofCell reports. Medicineen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectHumansen
dc.subjectNAD/metabolismen
dc.subjectSequestosome-1 Protein/metabolismen
dc.subjectAntioxidants/metabolismen
dc.subjectNF-E2-Related Factor 2/geneticsen
dc.subjectOxidation-Reductionen
dc.subjectInflammation/drug therapyen
dc.subjectR Medicineen
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleBoosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjectsen
dc.typeJournal articleen

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