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Effect of age, sex, and morbidity count on trial attrition : meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials

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dc.contributor.authorLees, Jennifer S
dc.contributor.authorHanlon, Peter
dc.contributor.authorButterly, Elaine W
dc.contributor.authorWild, Sarah H
dc.contributor.authorMair, Frances S
dc.contributor.authorTaylor, Rod S
dc.contributor.authorGuthrie, Bruce
dc.contributor.authorGillies, Katie
dc.contributor.authorDias, Sofia
dc.contributor.authorWelton, Nicky J
dc.contributor.authorMcAllister, David A
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2023-07-18T08:41:01Z
dc.date.available2023-07-18T08:41:01Z
dc.date.issued2022-09-01
dc.descriptionFunding JSL is funded by a Chief Scientist Office (Scotland) Postdoctoral Lectureship Award (PCL/20/10). DAM is funded via an Intermediate Clinical Fellowship and Beit Fellowship from the Wellcome Trust, who also supported other costs related to this project such as data access costs and database licences (201492/Z/16/Z). PH is funded through a clinical research training fellowship from the Medical Research Council (grant reference MR/S021949/1). The funders had no role in considering the study design or in the collection, analysis, interpretation of data, writing of the report, or decision to submit the article for publication. Competing interests All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: support from the Chief Scientist Office (Scotland), Wellcome Trust, and UK Medical Research Council for the submitted work; outside the submitted work, JSL has received personal honorariums from Bristol Myers Squibb, Pfizer, and Astra Zeneca. Acknowledgments This study, carried out under Yale University Open Data Access project number 2017-1746, used data obtained from the Yale University Open Data Access Project, which has an agreement with Janssen Research and Development. The interpretation and reporting of research using this data are solely the responsibility of the authors and does not necessarily represent the official views of the Yale University Open Data Access Project or Janssen Research and Development. This study was also carried out under ClinicalStudyDataRequest.com project number 1732, used data from the ClinicalStudyDataRequest.com repository, who provided data from Boehringer-Ingelheim, GSK, Lilly, Roche, Takeda, and Sanofi. The interpretation and reporting of research using these data are solely the responsibility of the authors and does not necessarily represent the official views of ClinicalStudyDataRequest.com or Boehringer-Ingelheim, GSK, Lilly, Roche, Takeda, or Sanofi.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1836711
dc.identifier218687201
dc.identifier0b324495-2ad6-468a-b09b-26eef345ee69
dc.identifier36936559
dc.identifier36936559
dc.identifier105016415957
dc.identifier.citationLees, J S, Hanlon, P, Butterly, E W, Wild, S H, Mair, F S, Taylor, R S, Guthrie, B, Gillies, K, Dias, S, Welton, N J & McAllister, D A 2022, 'Effect of age, sex, and morbidity count on trial attrition : meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials', BMJ Medicine, vol. 1, no. 1, e000217. https://doi.org/10.1136/bmjmed-2022-000217en
dc.identifier.doi10.1136/bmjmed-2022-000217
dc.identifier.issn2754-0413
dc.identifier.otherPubMedCentral: PMC9978693
dc.identifier.otherORCID: /0000-0001-7890-2854/work/139352205
dc.identifier.urihttps://hdl.handle.net/2164/21241
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=105016415957&partnerID=8YFLogxKen
dc.language.isoeng
dc.relation.ispartofBMJ Medicineen
dc.subjectclinical trialen
dc.subjectinternal medicineen
dc.subjectmedicineen
dc.subjectresearch designen
dc.subjectR Medicine (General)en
dc.subjectInternal Medicineen
dc.subjectWellcome Trusten
dc.subject201492/Z/16/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/S021949/1en
dc.subjectChief Scientist Office (CSO)en
dc.subjectPCL/20/10en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleEffect of age, sex, and morbidity count on trial attrition : meta-analysis of individual participant level data from phase 3/4 industry funded clinical trialsen
dc.typeJournal articleen

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