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Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure : An Exploratory Proof-of-Concept Trial

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dc.contributor.authorChowdary, Pratima
dc.contributor.authorAgarwal, Banwari
dc.contributor.authorPeralta, Maria Rita
dc.contributor.authorBhagani, Sanjay
dc.contributor.authorLee, Simon
dc.contributor.authorGoldring, James
dc.contributor.authorLipman, Marc
dc.contributor.authorWaqif, Emal
dc.contributor.authorPhillips, Mark
dc.contributor.authorPhilippou, Helen
dc.contributor.authorFoley, Jonathan H
dc.contributor.authorMutch, Nicola J
dc.contributor.authorAriëns, Robert A S
dc.contributor.authorStringer, Kathleen A
dc.contributor.authorRicciardi, Federico
dc.contributor.authorWatissée, Marie
dc.contributor.authorHughes, Derralynn
dc.contributor.authorNathwani, Amit
dc.contributor.authorRiddell, Anne
dc.contributor.authorPatch, David
dc.contributor.authorBuckley, Jim
dc.contributor.authorDe Neef, Mark
dc.contributor.authorDimber, Rahul
dc.contributor.authorDiaz-Garcia, Cecilia
dc.contributor.authorPatel, Honey
dc.contributor.authorNandani, Aarti
dc.contributor.authorDissanayake, Upuli
dc.contributor.authorChadwick, Nick
dc.contributor.authorAlkhatip, Ahmed A A M M
dc.contributor.authorWatkinson, Peter
dc.contributor.authorRaith, Eamon
dc.contributor.authorSingh, Suveer
dc.contributor.authorWolff, Tony
dc.contributor.authorJha, Rajeev
dc.contributor.authorBrill, Simon E
dc.contributor.authorBakhai, Ameet
dc.contributor.authorEvans, Alison
dc.contributor.authorGilani, Farhat
dc.contributor.authorGomez, Keith
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2023-10-26T15:48:00Z
dc.date.available2023-10-26T15:48:00Z
dc.date.issued2023-09-08
dc.descriptionAcknowledgments We would like to extend our sincerest gratitude to all the colleagues and hospital staff who worked tirelessly throughout the pandemic and without whom this work would not have been possible. Firstly, we would like to thank our colleagues in the intensive care unit (ICU), in particular the matrons, Sean Carroll and Sinead Hanton, and research nurses, Filipe Helder and Amitaa Maharajh for their support, and bedside nurses who bore the responsibility of drug administration. We would also like to extend our thanks to ICU consultants who acted as professional legal consultees on behalf of critical care patients. Equally, we would like to thank colleagues within the respiratory team. Their expertise was instrumental to our role in treating patients on 8N and 8E wards. A special mention to lead Nurse Mary Emerson; we were grateful for her knowledge, support and for facilitating the training for the nebulizer and drug administration on the wards. We would like to thank Aarti Nandani and all the staff in the Royal Free clinical trials pharmacy for their immense support throughout the whole pandemic, especially considering their ever-increasing workload at the time. Thanks also to the HSL coagulation laboratory, the Trust R&D department and all the staff working to cover during a very challenging time. We are also very grateful to the Royal Free charity for funding this study. Finally, we would like to thank all the clinical nurses, physiotherapists, research data managers and healthcare professionals within the Haemophilia department (and wider hospital) for all their many efforts in supporting this study. This trial was overseen by an independent data monitoring committee, chaired by Najib Rahman, Director of the Oxford Respiratory Trials Unit, University of Oxford and comprises the following committee members: Mike Makris, Jonathan Silversides and Henry Watson. Funding Royal Free Charity Trust Fund 35 provided funding for this study. The study drug was provided by Boehringer Ingelheim (BI). BI had no role in the design, analysis, or interpretation of the results. They were given the opportunity to review the manuscript for medical and scientific accuracy since it relates to BI substances and intellectual property considerations.en
dc.description.statusPeer revieweden
dc.format.extent17
dc.format.extent1575315
dc.identifier282026655
dc.identifier7dfd4084-038f-4659-84db-80876d3eeab7
dc.identifier37762789
dc.identifier85172811153
dc.identifier.citationChowdary, P, Agarwal, B, Peralta, M R, Bhagani, S, Lee, S, Goldring, J, Lipman, M, Waqif, E, Phillips, M, Philippou, H, Foley, J H, Mutch, N J, Ariëns, R A S, Stringer, K A, Ricciardi, F, Watissée, M, Hughes, D, Nathwani, A, Riddell, A, Patch, D, Buckley, J, De Neef, M, Dimber, R, Diaz-Garcia, C, Patel, H, Nandani, A, Dissanayake, U, Chadwick, N, Alkhatip, A A A M M, Watkinson, P, Raith, E, Singh, S, Wolff, T, Jha, R, Brill, S E, Bakhai, A, Evans, A, Gilani, F & Gomez, K 2023, 'Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure : An Exploratory Proof-of-Concept Trial', Journal of Clinical Medicine, vol. 12, no. 18, 5848. https://doi.org/10.3390/jcm12185848en
dc.identifier.doi10.3390/jcm12185848
dc.identifier.iss18en
dc.identifier.issn2077-0383
dc.identifier.otherPubMedCentral: PMC10531875
dc.identifier.otherORCID: /0000-0002-7452-0813/work/169538829
dc.identifier.urihttps://hdl.handle.net/2164/22042
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Medicineen
dc.subjectacute respiratory illnessen
dc.subjectcritical careen
dc.subjecttargeted therapyen
dc.subjectCOVID-19 pandemicen
dc.subjectnebulizationen
dc.subjectfibrinolyticsen
dc.subjectrecombinant tissue plasminogen activatoren
dc.subjectR Medicineen
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleNebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure : An Exploratory Proof-of-Concept Trialen
dc.typeJournal articleen

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