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Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice

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dc.contributor.authorMorrice, Nicola
dc.contributor.authorMcIlroy, George
dc.contributor.authorTammireddy, Sheshu R.
dc.contributor.authorReekie, Jennifer
dc.contributor.authorShearer, Kirsty D.
dc.contributor.authorDoherty, Mary K
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorWhitfield, Phillip D.
dc.contributor.authorMody, Nimesh
dc.contributor.institutionUniversity of Aberdeen.Centre for Genome-Enabled Biology and Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2017-03-07T11:28:48Z
dc.date.available2017-03-07T11:28:48Z
dc.date.issued2017-03-03
dc.descriptionThe authors would like to thank undergraduate student Aleksandra Kowalczuk (University of Aberdeen) for assisting in experiments and Dr. Emma K. Lees (School of Health Sciences, Liverpool Hope University, Liverpool, UK) for invaluable discussions concerning the regulation of FGF21. We thank Dr. Calum Sutherland and Dr. Amy Cameron (both Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK) for technical support and expertise in performing hepatocyte studies. Fenretinide was a generous gift of T. Martin (Johnson & Johnson, New Brunswick, NJ) and U. Thumeer (Cilag AG, Schaffhausen, Switzerland), for use completely without restriction or obligation. Quantitative-PCR was carried out using the qPCR Core Facility (Institute of Medical Sciences, University of Aberdeen). RNA-sequencing was carried out at the University of Aberdeen Centre for Genome Enabled Biology and Medicine. Pancreas histology was performed by Dr Linda Davidson (Department of Histology, Aberdeen Royal Infirmary, NHS Grampian, Foresterhill Health Campus, Aberdeen, UK). This study was supported by the British Heart Foundation Intermediate Basic Research Fellowship FS/09/026 to N. Mody, RCUK fellowship to MD, EFSD/Lilly Programme Grant to MD and N. Mody, Tenovus Scotland grants G10/04 and G14/14 to N. Mody, University of Aberdeen Centre for Genome Enabled Biology and Medicine (CGEBM) PhD studentship to N. Morrice and Biotechnology and Biological Sciences Research Council studentship to GDM.en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent1611917
dc.identifier85606497
dc.identifier92bde6e9-a97f-4c09-b910-0db00db873b1
dc.identifier85014626188
dc.identifier.citationMorrice, N, McIlroy, G, Tammireddy, S R, Reekie, J, Shearer, K D, Doherty, M K, Delibegovic, M, Whitfield, P D & Mody, N 2017, 'Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice', Scientific Reports, vol. 7, 43782 . https://doi.org/10.1038/srep43782en
dc.identifier.doi10.1038/srep43782
dc.identifier.issn2045-2322
dc.identifier.otherORCID: /0000-0003-4230-4355/work/102133118
dc.identifier.otherORCID: /0000-0002-2215-7952/work/147568298
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847583
dc.identifier.urihttp://hdl.handle.net/2164/8293
dc.identifier.vol7en
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectendocrine system and metabolic diseasesen
dc.subjectgene expression analysisen
dc.subjectmetabolic syndromeen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectFS/09/026en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectUK Research and Innovation (UKRI)en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleElevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in miceen
dc.typeJournal articleen

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