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The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture

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dc.contributor.authorFaber, Benjamin G
dc.contributor.authorFrysz, Monika
dc.contributor.authorZheng, Jaiyi
dc.contributor.authorLin, Huandong
dc.contributor.authorFlynn, Kaitlyn A.
dc.contributor.authorEbsim, Raja
dc.contributor.authorSaunders, Fiona
dc.contributor.authorBeynon, Rhona
dc.contributor.authorGregory, Jenny
dc.contributor.authorAspden, Richard Malcolm
dc.contributor.authorHarvey, Nicholas C
dc.contributor.authorLindner, Claudia
dc.contributor.authorCootes, Timothy
dc.contributor.authorEvans, David M.
dc.contributor.authorSmith, George Davey
dc.contributor.authorGao, Xin
dc.contributor.authorWang, Sijia
dc.contributor.authorKemp, John P.
dc.contributor.authorTobias, Jonathan H.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.MRC/Versus Arthritis Centre for Musculoskeletal Health and Worken
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2025-01-30T15:00:01Z
dc.date.available2025-01-30T15:00:01Z
dc.date.issued2025-02-01
dc.descriptionThe authors would like to thank the Musculoskeletal Research Unit patient and public involvement group at the University of Bristol for their input into planning our research. This work has been conducted using the UK Biobank resource (application number 17295). BGF is supported by an NIHR Academic Clinical Lectureship, an Academy of Medical Sciences Starter Grant (SGL030\1057) and was previously supported by a Medical Research Council (MRC) Clinical Research Training Fellowship (MR/S021280/1). RE, MF, FS were supported, and this work is funded by a Wellcome Trust collaborative award (209233/Z/17/Z). MF conducted this work whilst working at the University of Bristol but is now employed by Boehringer Ingleheim UK and Ireland. CL is funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (223267/Z/21/Z). This research was funded in whole, or in part, by the Wellcome Trust [Grant numbers 080280/Z/06/Z, 20378/Z/16/Z, 223267/Z/21/Z]. For the purpose of open access, the authors have applied a creative commons attribution license (CC BY) public copyright licence to any Author Accepted Manuscript version arising from this submission. NCH acknowledges support from the Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001] and National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. JPK is funded by a National Health and Medical Research Council (Australia) Investigator grant (GNT1177938). SW is supported by the ‘Strategic Priority Research Program’ of the Chinese Academy of Sciences (Grant No. XDB38020400) and Shanghai Municipal Science and Technology Major Project, Grant No.2017SHZDZX01. XG is supported by Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01).en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1048263
dc.identifier298574893
dc.identifier6a2cbf9c-a894-4ea6-8659-84757311e8aa
dc.identifier39574169
dc.identifier85217881515
dc.identifier.citationFaber, B G, Frysz, M, Zheng, J, Lin, H, Flynn, K A, Ebsim, R, Saunders, F, Beynon, R, Gregory, J, Aspden, R M, Harvey, N C, Lindner, C, Cootes, T, Evans, D M, Smith, G D, Gao, X, Wang, S, Kemp, J P & Tobias, J H 2025, 'The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture', Human Molecular Genetics, vol. 34, no. 3, pp. 207-217. https://doi.org/10.1093/hmg/ddae169en
dc.identifier.doi10.1093/hmg/ddae169
dc.identifier.iss3en
dc.identifier.issn0964-6906
dc.identifier.otherORCID: /0000-0001-7130-6777/work/174358105
dc.identifier.urihttps://hdl.handle.net/2164/24964
dc.identifier.urlhttps://abdn.elsevierpure.com/en/publications/6a2cbf9c-a894-4ea6-8659-84757311e8aaen
dc.identifier.vol34en
dc.language.isoeng
dc.relation.ispartofHuman Molecular Geneticsen
dc.subjectgenome wide association studyen
dc.subjectosteoarthritisen
dc.subjecthip shapeen
dc.subjecthip fractureen
dc.subjectMendelian randomisationen
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subjectLinken
dc.subject.lccRen
dc.titleThe genetic architecture of hip shape and its role in the development of hip osteoarthritis and fractureen
dc.typeJournal articleen

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