University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

Simple item page
dc.contributor.authorGonçalves, Samuel M.
dc.contributor.authorDuarte-Oliveira, Cláudio
dc.contributor.authorCampos, Cláudia F.
dc.contributor.authorAimanianda, Vishukumar
dc.contributor.authorter Horst, Rob
dc.contributor.authorLeite, Luis
dc.contributor.authorMercier, Toine
dc.contributor.authorPereira, Paulo
dc.contributor.authorFernández-García, Miguel
dc.contributor.authorAntunes, Daniela
dc.contributor.authorRodrigues, Cláudia S.
dc.contributor.authorBarbosa-Matos, Catarina
dc.contributor.authorGaifem, Joana
dc.contributor.authorMesquita, Inês
dc.contributor.authorMarques, António
dc.contributor.authorOsório, Nuno S.
dc.contributor.authorTorrado, Egídio
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorCosta, Sandra
dc.contributor.authorJoosten, Leo A.B.
dc.contributor.authorLagrou, Katrien
dc.contributor.authorMaertens, Johan
dc.contributor.authorLacerda, João F
dc.contributor.authorCampos Jr, António
dc.contributor.authorBrown, Gordon D.
dc.contributor.authorBrakhage, Axel A
dc.contributor.authorBarbas, Coral
dc.contributor.authorSilvestre, Ricardo
dc.contributor.authorvan de Veerdonk, Frank L.
dc.contributor.authorChamilos, Georgios
dc.contributor.authorNetea, Mihai G.
dc.contributor.authorLatgé, Jean-Paul
dc.contributor.authorCunha, Cristina
dc.contributor.authorCarvalho, Agostinho
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2020-06-15T18:05:01Z
dc.date.available2020-06-15T18:05:01Z
dc.date.issued2020
dc.descriptionAcknowledgements This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01- 0145-FEDER-000013), the Fundação para a Ciência e Tecnologia (FCT) (SFRH/BD/136814/2018 to S.M.G., SFRH/BD/141127/2018 to C.D.O., PD/BD/137680/2018 to D.A., IF/00474/2014 to N.S.O., IF/01390/2014 to E.T., IF/00959/2014 to S.C., IF/00021/2014 to R.S., PTDC/SAU-SER/29635/2017 and CEECIND/04601/2017 to C.C., and CEECIND/03628/2017 to A.C.), the Institut Mérieux (Mérieux Research Grant 2017 to C.C.), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Research Grant 2017 to A.C.). M.G.N. was supported by a Spinoza grant of the Netherlands Organization for Scientific Research. A.A.B. was supported by the Deutsche Forschungsgemeinschaft Collaborative Research Center/Transregio TR124 FungiNet (project A1). G.D.B. was funded by the Wellcome Trust (102705), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1).en
dc.description.statusPeer revieweden
dc.format.extent4989992
dc.identifier160372265
dc.identifier1cba4992-2def-42ba-a1b8-45ab8c5e3412
dc.identifier32385235
dc.identifier85084721395
dc.identifier000533936800006
dc.identifier.citationGonçalves, S M, Duarte-Oliveira, C, Campos, C F, Aimanianda, V, ter Horst, R, Leite, L, Mercier, T, Pereira, P, Fernández-García, M, Antunes, D, Rodrigues, C S, Barbosa-Matos, C, Gaifem, J, Mesquita, I, Marques, A, Osório, N S, Torrado, E, Rodrigues, F, Costa, S, Joosten, L A B, Lagrou, K, Maertens, J, Lacerda, J F, Campos Jr, A, Brown, G D, Brakhage, A A, Barbas, C, Silvestre, R, van de Veerdonk, F L, Chamilos, G, Netea, M G, Latgé, J-P, Cunha, C & Carvalho, A 2020, 'Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity', Nature Communications, vol. 11, 2282. https://doi.org/10.1038/s41467-020-16120-zen
dc.identifier.doi10.1038/s41467-020-16120-z
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC7210971
dc.identifier.urihttps://hdl.handle.net/2164/14501
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85084721395&partnerID=8YFLogxKen
dc.identifier.vol11en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectAspergillusen
dc.subjectmelaninen
dc.subjectimmunometabolismen
dc.subjectglycolysisen
dc.subjectcalciumen
dc.subjectmacrophageen
dc.subjectantifungal immunityen
dc.subjectinvasive pulmonary aspergillosisen
dc.subjectACTIVATIONen
dc.subjectASPERGILLUS-FUMIGATUSen
dc.subjectPHAGOCYTOSISen
dc.subjectDENDRITIC CELLen
dc.subjectCONIDIAen
dc.subjectMTORen
dc.subjectSUCCINATE-DEHYDROGENASEen
dc.subjectINHIBITIONen
dc.subjectBIOSYNTHESISen
dc.subjectCELLULAR-METABOLISMen
dc.subjectR Medicine (General)en
dc.subjectGeneral Physics and Astronomyen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectWellcome Trusten
dc.subject102705en
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titlePhagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunityen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Goncalves_etal_NatComm_Phagosomal_VOR.pdf
Size:
4.76 MB
Format:
Adobe Portable Document Format
Download

Collections

All research