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Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

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dc.contributor.authorNicod, Jérôme
dc.contributor.authorDavies, Robert W.
dc.contributor.authorCai, Na
dc.contributor.authorHassett, Carl
dc.contributor.authorGoodstadt, Leo
dc.contributor.authorCosgrove, Cormac
dc.contributor.authorYee, Benjamin K.
dc.contributor.authorLionikaite, Vikte
dc.contributor.authorMcIntyre, Rebecca E.
dc.contributor.authorRemme, Carol Ann
dc.contributor.authorLodder, Elisabeth M.
dc.contributor.authorGregory, Jennifer S.
dc.contributor.authorHough, Tertius
dc.contributor.authorJoynson, Russell
dc.contributor.authorPhelps, Hayley
dc.contributor.authorNell, Barbara
dc.contributor.authorRowe, Clare
dc.contributor.authorWood, Joe
dc.contributor.authorWalling, Alison
dc.contributor.authorBopp, Nasrin
dc.contributor.authorBhomra, Amarjit
dc.contributor.authorHernandez-Pliego, Polinka
dc.contributor.authorCallebert, Jacques
dc.contributor.authorAspden, Richard M.
dc.contributor.authorTalbot, Nick P.
dc.contributor.authorRobbins, Peter A.
dc.contributor.authorHarrison, Mark
dc.contributor.authorFray, Martin
dc.contributor.authorLaunay, Jean-Marie
dc.contributor.authorPinto, Yigal M.
dc.contributor.authorBlizard, David A.
dc.contributor.authorBezzina, Connie R.
dc.contributor.authorAdams, David J.
dc.contributor.authorFranken, Paul
dc.contributor.authorWeaver, Tom
dc.contributor.authorWells, Sara
dc.contributor.authorBrown, Steve D. M.
dc.contributor.authorPotter, Paul K.
dc.contributor.authorKlenerman, Paul
dc.contributor.authorLionikas, Arimantas
dc.contributor.authorMott, Richard
dc.contributor.authorFlint, Jonathan
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.date.accessioned2017-01-05T00:31:14Z
dc.date.available2017-01-05T00:31:14Z
dc.date.embargoedUntil2016-11-24
dc.date.issued2016-08-31
dc.descriptionThe authors wish to acknowledge excellent technical assistance from A. Kurioka, L. Swadling, C. de Lara, J. Ussher, R. Townsend, S. Lionikaite, A.S. Lionikiene, R. Wolswinkel and I. van der Made. We would like to thank T.M. Keane and A.G. Doran for their help in annotating variants and adding the FVB/NJ strain to the MGP. We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics and the Wellcome Trust Sanger Institute for the generation of the sequencing data. This work was funded by Wellcome Trust grant 090532/Z/09/Z (J.F.). Primary phenotyping of the mice was supported by the Mary Lyon Centre and Mammalian Genetics Unit (Medical Research Council, UK Hub grant G0900747 91070 and Medical Research Council, UK grant MC U142684172). D.A.B. acknowledges support from NIH R01AR056280. The sleep work was supported by the state of Vaud (Switzerland) and the Swiss National Science Foundation (SNF 14694 and 136201 to P.F.). The ECG work was supported by the Netherlands CardioVascular Research Initiative (Dutch Heart Foundation, Dutch Federation of University Medical Centres, Netherlands Organization for Health Research and Development and the Royal Netherlands Academy of Sciences) PREDICT project, InterUniversity Cardiology Institute of the Netherlands (ICIN; 061.02; C.A.R. and C.R.B.). N.C. is supported by the Agency of Science, Technology and Research (A*STAR) Graduate Academy. R.W.D. is supported by a grant from the Wellcome Trust (097308/Z/11/Z).en
dc.description.statusPeer revieweden
dc.format.extent7
dc.format.extent499668
dc.identifier65443434
dc.identifier60bb00f1-9590-4fa9-90bf-a250761647be
dc.identifier84976878592
dc.identifier.citationNicod, J, Davies, R W, Cai, N, Hassett, C, Goodstadt, L, Cosgrove, C, Yee, B K, Lionikaite, V, McIntyre, R E, Remme, C A, Lodder, E M, Gregory, J S, Hough, T, Joynson, R, Phelps, H, Nell, B, Rowe, C, Wood, J, Walling, A, Bopp, N, Bhomra, A, Hernandez-Pliego, P, Callebert, J, Aspden, R M, Talbot, N P, Robbins, P A, Harrison, M, Fray, M, Launay, J-M, Pinto, Y M, Blizard, D A, Bezzina, C R, Adams, D J, Franken, P, Weaver, T, Wells, S, Brown, S D M, Potter, P K, Klenerman, P, Lionikas, A, Mott, R & Flint, J 2016, 'Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing', Nature Genetics, vol. 48, no. 8, pp. 912-918. https://doi.org/10.1038/ng.3595en
dc.identifier.doi10.1038/ng.3595
dc.identifier.iss8en
dc.identifier.issn1061-4036
dc.identifier.otherORCID: /0000-0002-0052-6171/work/76975849
dc.identifier.urihttp://hdl.handle.net/2164/7944
dc.identifier.vol48en
dc.language.isoeng
dc.relation.ispartofNature Geneticsen
dc.subjectR Medicineen
dc.subjectQH426 Geneticsen
dc.subjectWellcome Trusten
dc.subject090532/Z/09/Zen
dc.subject097308/Z/11/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectG0900747 91070en
dc.subjectU142684172en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.subject.lccQH426en
dc.titleGenome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencingen
dc.typeJournal articleen

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