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Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure

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dc.contributor.authorPiedrafita, Gabriel
dc.contributor.authorVarma, Sreejith J.
dc.contributor.authorCastro, Cecilia
dc.contributor.authorMessner, Christoph B.
dc.contributor.authorSzyrwiel, Lukasz
dc.contributor.authorGriffin, Julian L.
dc.contributor.authorRalser, Markus
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2022-01-18T19:48:01Z
dc.date.available2022-01-18T19:48:01Z
dc.date.issued2021-12
dc.descriptionAcknowledgments We thank Markus Keller and members of the Ralser group for valuable discussions and critical comments, Olivier Languin-Cattoen and Maria Ouvarova for help in the nonenzymatic reaction screening, and Dr. Jae-Hun Jeoung (Humboldt University Berlin) for assistance in carrying out anaerobic reactions. This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001134), the UK Medical Research Council (FC001134), and the Wellcome Trust (FC001134). MR received support from the Wellcome Trust (200829/Z/16/Z) and the Ministry of Education and Research (BMBF), as part of the National Research Node ‘Mass spectrometry in Systems Medicine (MSCoresys), under grant agreement 031L0220A. JLG was supported by the Medical Research Council UK (MR/P011705/1, MC_UP_A090_1006). GP acknowledges support by a Talento program fellowship from Comunidad de Madrid. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent23
dc.format.extent2260825
dc.identifier211922097
dc.identifiercffcf0bc-6e31-4fef-a60c-dd96fcabfd8b
dc.identifier85121916183
dc.identifier34871299
dc.identifier.citationPiedrafita, G, Varma, S J, Castro, C, Messner, C B, Szyrwiel, L, Griffin, J L & Ralser, M 2021, 'Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure', PLoS Biology, vol. 19, no. 12, e3001468. https://doi.org/10.1371/journal.pbio.3001468en
dc.identifier.doi10.1371/journal.pbio.3001468
dc.identifier.iss12en
dc.identifier.issn1544-9173
dc.identifier.otherORCID: /0000-0003-1336-7744/work/106597843
dc.identifier.urihttps://hdl.handle.net/2164/17914
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85121916183&partnerID=8YFLogxKen
dc.identifier.vol19en
dc.language.isoeng
dc.relation.ispartofPLoS Biologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectQH301 Biologyen
dc.subjectGeneral Neuroscienceen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Immunology and Microbiologyen
dc.subjectGeneral Agricultural and Biological Sciencesen
dc.subjectCancer Research UKen
dc.subjectFC001134en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/P011705/1en
dc.subjectWellcome Trusten
dc.subject200829/Z/16/Zen
dc.subject.lccQH301en
dc.titleCysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structureen
dc.typeJournal articleen

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