University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer

Simple item page
dc.contributor.authorGamble, David T
dc.contributor.authorRoss, James
dc.contributor.authorKhan, Hilal
dc.contributor.authorUnger, Andreas
dc.contributor.authorCheyne, Lesley
dc.contributor.authorRudd, Amelia
dc.contributor.authorSaunders, Fiona
dc.contributor.authorSrivanasan, Janaki
dc.contributor.authorKamya, Sylvia
dc.contributor.authorHorgan, Graham
dc.contributor.authorHannah, Andrew
dc.contributor.authorBaliga, Santosh
dc.contributor.authorTocchetti, Carlo Gabriele
dc.contributor.authorUrquhart, Gordon
dc.contributor.authorLinke, Wolfgang A
dc.contributor.authorMasannat, Yazan
dc.contributor.authorMustafa, Ahmed
dc.contributor.authorFuller, Mairi
dc.contributor.authorElsberger, Beatrix
dc.contributor.authorSharma, Ravi
dc.contributor.authorDawson, Dana
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2023-10-20T11:49:00Z
dc.date.available2023-10-20T11:49:00Z
dc.date.issued2023-10-17
dc.descriptionAcknowledgments The fellow (Dr Gamble) recruited participants, scheduled, coordinated, and performed all clinical imaging investigations, patients skeletal muscle biopsies and venesection, conducted mitochondrial copy number analysis of muscle biopsies under supervision, analyzed all data, performed statistical analyses under supervision, and drafted this article. H. Khan and A. Rudd helped with the investigations and reviewed and contributed to this article. S. Baliga provided the healthy volunteer skeletal muscle biopsies. Dr Ross designed and developed the protocol for cardiac and skeletal muscle spectroscopy. L. Cheyne supervised muscle biopsy analyses. Drs Unger and Linke performed the skeletal muscle transmission electron microscopy and immunofluorescence confocal microscopy investigations. Dr Horgan is the study statistician. Drs Urquhart, Masannat, Elsberger, Fuller, Mustafa, and Sharma identified and recruited participants and reviewed and contributed to this article. Drs Hannah, Sharma, and Saunders contributed to the design of the study. D. Dawson (PI) designed the study, obtained funding (together with Drs Sharma and Masannat) and regulatory approvals, supervised the unfolding of the study, its analyses and revised the article drafts. Sources of Funding Tenovus Scotland G18.01, D. Dawson and Dr Sharma, Friends of Anchor 2019, Grampian National Health Service-Endowments (Drs Sharma and Masannat), British Health Foundation PG/18/35/33786 to D. Dawson funded DG salary and BHF FS/RTF/20/30009 to D. Dawson funded AR salary.en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent638966
dc.identifier281990061
dc.identifier52b0d60c-8bcc-41d5-9917-1791d6b96a72
dc.identifier37847761
dc.identifier85174750554
dc.identifier.citationGamble, D T, Ross, J, Khan, H, Unger, A, Cheyne, L, Rudd, A, Saunders, F, Srivanasan, J, Kamya, S, Horgan, G, Hannah, A, Baliga, S, Tocchetti, C G, Urquhart, G, Linke, W A, Masannat, Y, Mustafa, A, Fuller, M, Elsberger, B, Sharma, R & Dawson, D 2023, 'Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer', Circulation. Cardiovascular imaging, vol. 16, no. 10, e015782, pp. 817-826. https://doi.org/10.1161/CIRCIMAGING.123.015782en
dc.identifier.doi10.1161/CIRCIMAGING.123.015782
dc.identifier.iss10en
dc.identifier.issn1941-9651
dc.identifier.otherPubMedCentral: PMC10581415
dc.identifier.otherORCID: /0000-0001-7984-6452/work/145113523
dc.identifier.otherORCID: /0000-0003-2815-4469/work/160846718
dc.identifier.urihttps://hdl.handle.net/2164/21971
dc.identifier.vol16en
dc.language.isoeng
dc.relation.ispartofCirculation. Cardiovascular imagingen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectBritish Heart Foundationen
dc.subjectPG/18/35/33786en
dc.subjectFS/RTF/20/30009en
dc.subject.lccRen
dc.titleImpaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Canceren
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gamble_etal_CCI_Impaired_Cardiac_And_VoR.pdf
Size:
623.99 KB
Format:
Adobe Portable Document Format
Download

Collections

All research