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Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains

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dc.contributor.authorSoto-Rojas, Luis O
dc.contributor.authorCampa-Córdoba, B. Berenice
dc.contributor.authorHarrington, Charles
dc.contributor.authorSalas-Casas, Andrés
dc.contributor.authorHernandes-Alejandro, Mario
dc.contributor.authorVillanueva-Fierro, Ignacio
dc.contributor.authorBravo-Muñoz, Marely
dc.contributor.authorGarcés-Ramírez, Linda
dc.contributor.authorDe La Cruz-López, Fidel
dc.contributor.authorOntiveros-Torres, Miguel Angel
dc.contributor.authorGevorkian, Goar
dc.contributor.authorPacheco-Herrero, Mar
dc.contributor.authorLuna-Muñoz, José
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2021-04-01T12:19:01Z
dc.date.available2021-04-01T12:19:01Z
dc.date.issued2021-04-01
dc.descriptionFunding: This work was supported by Fondo Nacional de Ciencia y Tecnologia, FONDOCyT, from the Ministry of Higher Education, Science and Technology, Dominican Republic (2015-3A2-127 to MP-H) and (2018-2019-2A3-208 to J.L.-M. and M.P.-H). Acknowledgments: The authors want to express their gratitude to the following: P. Davies†(Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder† (North Western, Chicago, IL, USA) for the generous gift of mAbs TG-3 and Alz-50, and Tau-1, Tau-5, and Tau-7, respectively; Tec. Amparo Viramontes Pintos for the handling of the brain tissue; support in the confocal microscopy unit of CIIDIR Durango, Instituto Politécnico Nacional; Union Medica University Clinic, Dominican Republic, for their support and collaboration in the development of this research project. We also want to express our gratitude to the Mexican families who have donated the brain of their loved ones affected by Alzheimer’s disease and made our research possible. This work is dedicated to the memory of José Raúl Mena López† . †Deceased.en
dc.description.statusPeer revieweden
dc.format.extent18
dc.format.extent59591441
dc.identifier190812061
dc.identifier6f8e92e8-4a38-4af6-89c5-11b7712dca3c
dc.identifier85103334888
dc.identifier33915754
dc.identifier000638660200001
dc.identifier.citationSoto-Rojas, L O, Campa-Córdoba, B B, Harrington, C, Salas-Casas, A, Hernandes-Alejandro, M, Villanueva-Fierro, I, Bravo-Muñoz, M, Garcés-Ramírez, L, De La Cruz-López, F, Ontiveros-Torres, M A, Gevorkian, G, Pacheco-Herrero, M & Luna-Muñoz, J 2021, 'Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains', International Journal of Molecular Sciences, vol. 22, no. 7, 3654. https://doi.org/10.3390/ijms22073654en
dc.identifier.doi10.3390/ijms22073654
dc.identifier.iss7en
dc.identifier.issn1422-0067
dc.identifier.otherunpaywall: 10.3390/ijms22073654
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415882
dc.identifier.urihttps://hdl.handle.net/2164/16167
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85103334888&partnerID=8YFLogxKen
dc.identifier.vol22en
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciencesen
dc.subjectAlzheimer’s diseaseen
dc.subjectfibrillar amyloiden
dc.subjectpyroglutamate-modified amyloid-beta peptidesen
dc.subjectneurovascular uniten
dc.subjectblood–brain barrieren
dc.subjectcaspase-5en
dc.subjectCaspase-5en
dc.subjectNeurovascular uniten
dc.subjectFibrillar amyloiden
dc.subjectPyroglutamate-modified amyloid-beta peptidesen
dc.subjectBlood–brain barrieren
dc.subjectR Medicineen
dc.subjectMolecular Biologyen
dc.subjectSpectroscopyen
dc.subjectCatalysisen
dc.subjectInorganic Chemistryen
dc.subjectComputer Science Applicationsen
dc.subjectPhysical and Theoretical Chemistryen
dc.subjectOrganic Chemistryen
dc.subject.lccRen
dc.titleInsoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brainsen
dc.typeJournal articleen

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