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Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing : a population-based study using human foetuses and the UK Biobank cohort

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dc.contributor.authorMihov, Mihail
dc.contributor.authorShoctor, Hannah
dc.contributor.authorDouglas, Alex
dc.contributor.authorHay, David C
dc.contributor.authorO'Shaughnessy, Peter J.
dc.contributor.authorIredale, John P
dc.contributor.authorShaw, Sophie
dc.contributor.authorFowler , Paul Alfred François
dc.contributor.authorGrassmann, Felix
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Statisticsen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2025-05-12T10:10:32Z
dc.date.available2025-05-12T10:10:32Z
dc.date.issued2025-04
dc.descriptionAcknowledgements The current study was conducted under the UK Biobank project 73446. The authors would like to thank (i) the Fowler team members, NHS Grampian research nurses and staff at the Pregnancy Counselling Service for their essential work in recruiting, collecting, and processing foetuses; (ii) the Centre for Genome Enabled Biology and Medicine, University of Aberdeen, for carrying out the RNA sequencing. The RNA sequencing data analysis was supported by use of the University of Aberdeen Maxwell High Performance Computer Cluster.en
dc.description.statusPeer revieweden
dc.format.extent18
dc.format.extent182670
dc.identifier300864754
dc.identifier8247ab12-e003-4c6e-9511-f5a6af0232eb
dc.identifier40074595
dc.identifier105000031097
dc.identifier.citationMihov, M, Shoctor, H, Douglas, A, Hay, D C, O'Shaughnessy, P J, Iredale, J P, Shaw, S, Fowler , P A F & Grassmann, F 2025, 'Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing : a population-based study using human foetuses and the UK Biobank cohort', EBioMedicine, vol. 114, 1055590. https://doi.org/10.1016/j.ebiom.2025.105590en
dc.identifier.doi10.1016/j.ebiom.2025.105590
dc.identifier.issn2352-3964
dc.identifier.otherORCID: /0000-0001-6606-1058/work/180268684
dc.identifier.otherORCID: /0000-0002-4831-9075/work/180268796
dc.identifier.otherORCID: /0000-0003-1390-7528/work/189636423
dc.identifier.urihttps://hdl.handle.net/2164/25393
dc.identifier.vol114en
dc.language.isoeng
dc.relation.ispartofEBioMedicineen
dc.subjectSubstantive connection via eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHumansen
dc.subjectFemaleen
dc.subjectPregnancyen
dc.subjectSmoking/adverse effectsen
dc.subjectUnited Kingdom/epidemiologyen
dc.subjectMaleen
dc.subjectMaternal Exposure/adverse effectsen
dc.subjectPrenatal Exposure Delayed Effects/epidemiologyen
dc.subjectBiological Specimen Banksen
dc.subjectMiddle Ageden
dc.subjectAdulten
dc.subjectGenomics/methodsen
dc.subjectFetus/metabolismen
dc.subjectAging/geneticsen
dc.subjectGenome-Wide Association Studyen
dc.subjectTranscriptomeen
dc.subjectCohort Studiesen
dc.subjectUK Biobanken
dc.subjectR Medicine (General)en
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subject.lccR1en
dc.titleLinking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing : a population-based study using human foetuses and the UK Biobank cohorten
dc.typeJournal articleen

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