Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors
| dc.contributor.author | Lockhart, Deborah E. A. | |
| dc.contributor.author | Schuettelkopf, Alexander | |
| dc.contributor.author | Blair, David E. | |
| dc.contributor.author | van Aalten, Daan M. F. | |
| dc.date.accessioned | 2018-12-04T11:30:08Z | |
| dc.date.available | 2018-12-04T11:30:08Z | |
| dc.date.issued | 2014-08-25 | |
| dc.description | We wish to thank the Dundee Drug Discovery Unit for access to the diversity set library and the European Synchrotron Radiation Facility, Grenoble, for time at the beamline. This work was supported by a Grant (G0900138) and a Wellcome Trust Senior Research Fellowship (WT087590MA) to D.M.F.v.A. D.E.A.L. is the recipient of a MRC Clinical Research Training Fellowship (G1100430). The structures have been deposited in the Protein Data Bank with accession codes 4TX6 and 4TXE. | en |
| dc.description.status | Peer reviewed | en |
| dc.format.extent | 9 | |
| dc.format.extent | 1753209 | |
| dc.identifier | 114869306 | |
| dc.identifier | 06974c8d-99fd-4e5d-9374-50d8bd9bacd7 | |
| dc.identifier | 25063338 | |
| dc.identifier | 84906214259 | |
| dc.identifier.citation | Lockhart, D E A, Schuettelkopf, A, Blair, D E & van Aalten, D M F 2014, 'Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors', FEBS Letters, vol. 588, no. 17, pp. 3282-3290. https://doi.org/10.1016/j.febslet.2014.07.015 | en |
| dc.identifier.doi | 10.1016/j.febslet.2014.07.015 | |
| dc.identifier.iss | 17 | en |
| dc.identifier.issn | 0014-5793 | |
| dc.identifier.other | PubMedCentral: PMC4158421 | |
| dc.identifier.other | ORCID: /0000-0002-4262-3842/work/76974404 | |
| dc.identifier.uri | http://hdl.handle.net/2164/11555 | |
| dc.identifier.vol | 588 | en |
| dc.language.iso | eng | |
| dc.relation.ispartof | FEBS Letters | en |
| dc.subject | Aspergillus fumigatus | en |
| dc.subject | Chitinases | en |
| dc.subject | Crystallography, X-Ray | en |
| dc.subject | Drug Evaluation, Preclinical | en |
| dc.subject | Enzyme Inhibitors | en |
| dc.subject | High-Throughput Screening Assays | en |
| dc.subject | Inhibitory Concentration 50 | en |
| dc.subject | Kinetics | en |
| dc.subject | Models, Molecular | en |
| dc.subject | Molecular Sequence Data | en |
| dc.subject | Protein Conformation | en |
| dc.subject | Journal Article | en |
| dc.subject | Research Support, Non-U.S. Gov't | en |
| dc.subject | R Medicine (General) | en |
| dc.subject | Wellcome Trust | en |
| dc.subject | WT087590MA | en |
| dc.subject | Medical Research Council (MRC) | en |
| dc.subject | G1100430 | en |
| dc.subject.lcc | R1 | en |
| dc.title | Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors | en |
| dc.type | Journal article | en |