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Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

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dc.contributor.authorUbah, Obinna C
dc.contributor.authorLake, Eric W
dc.contributor.authorGunaratne, Gihan S
dc.contributor.authorGallant, Joseph P
dc.contributor.authorFernie, Marie
dc.contributor.authorRobertson, Austin J
dc.contributor.authorMarchant, Jonathan S
dc.contributor.authorBold, Tyler D
dc.contributor.authorLanglois, Ryan A
dc.contributor.authorMatchett, William E
dc.contributor.authorThiede, Joshua M
dc.contributor.authorShi, Ke
dc.contributor.authorYin, Lulu
dc.contributor.authorMoeller, Nicholas H
dc.contributor.authorBanerjee, Surajit
dc.contributor.authorFerguson, Laura
dc.contributor.authorKovaleva, Marina
dc.contributor.authorPorter, Andrew J
dc.contributor.authorAihara, Hideki
dc.contributor.authorLeBeau, Aaron M
dc.contributor.authorBarelle, Caroline J
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2021-12-23T11:21:01Z
dc.date.available2021-12-23T11:21:01Z
dc.date.issued2021-12-16
dc.descriptionAcknowledgements This work was supported by the Chief Scientist Office, Scottish Government, Grant COV/ABN/20/01 (Elasmogen, Ltd.), a 2018 Prostate Cancer Foundation Challenge Award (AML), a 2013 Prostate Cancer Foundation Young Investigator Award (AML), NCI R01s CA237272, CA233562, and CA245922 (AML). WEM was supported by the NIH T32 HL007741 and JMT by the NIH T32 AI055433. JSM was funded by NIGMS R01 GM088790. HA was funded by NIGMS R35 GM118047 and NCI P01 CA234228. X-ray diffraction data were collected at the Northeastern Collaborative Access Team beamlines, which are funded by the US National Institutes of Health (NIGMS P30 GM124165). The Pilatus 6M detector on 24-ID-C beamline is funded by a NIH-ORIP HEI grant (S10 RR029205). We thank the Marco Pravetoni lab for providing training and access to the OctetRED96e for BLI experiments.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent2980097
dc.identifier210581659
dc.identifier3966c028-7a55-4d52-b341-224a6c667849
dc.identifier34916516
dc.identifier85121420979
dc.identifier.citationUbah, O C, Lake, E W, Gunaratne, G S, Gallant, J P, Fernie, M, Robertson, A J, Marchant, J S, Bold, T D, Langlois, R A, Matchett, W E, Thiede, J M, Shi, K, Yin, L, Moeller, N H, Banerjee, S, Ferguson, L, Kovaleva, M, Porter, A J, Aihara, H, LeBeau, A M & Barelle, C J 2021, 'Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography', Nature Communications, vol. 12, no. 1, 7325. https://doi.org/10.1038/s41467-021-27611-yen
dc.identifier.doi10.1038/s41467-021-27611-y
dc.identifier.iss1en
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/2164/17761
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAntibody fragment therapyen
dc.subjectProtein designen
dc.subjectR Medicineen
dc.subjectChief Scientist Office (CSO)en
dc.subjectCOV/ABN/20/01en
dc.subjectProstate Cancer UKen
dc.subjectCA245922en
dc.subjectCA233562en
dc.subjectNCI R01s CA237272en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleMechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallographyen
dc.typeJournal articleen

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