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A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

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dc.contributor.authorSchwab, Karima
dc.contributor.authorFrahm, Silke
dc.contributor.authorHorsley, David
dc.contributor.authorRickard, Janet E
dc.contributor.authorMelis, Valeria
dc.contributor.authorGoatman, Elizabeth A
dc.contributor.authorMagbagbeolu, Mandy
dc.contributor.authorDouglas, Morag
dc.contributor.authorLeith, Michael G
dc.contributor.authorBaddeley, Thomas C.
dc.contributor.authorStorey, John M D
dc.contributor.authorRiedel, Gernot
dc.contributor.authorWischik, Claude M
dc.contributor.authorHarrington, Charles R
dc.contributor.authorTheuring, Franz
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.date.accessioned2018-02-01T13:10:08Z
dc.date.available2018-02-01T13:10:08Z
dc.date.issued2018-01-10
dc.descriptionThe authors acknowledge Heide Lueck for excellent technical assistance and for maintenance of animals. AMS Biotechnology generated monoclonal antibodies from recombinant α-Syn prepared by JR.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent6999156
dc.identifier115416241
dc.identifierb0597bf5-33b0-4874-82ed-b0faf565b61b
dc.identifier29375308
dc.identifier85041335338
dc.identifier.citationSchwab, K, Frahm, S, Horsley, D, Rickard, J E, Melis, V, Goatman, E A, Magbagbeolu, M, Douglas, M, Leith, M G, Baddeley, T C, Storey, J M D, Riedel, G, Wischik, C M, Harrington, C R & Theuring, F 2018, 'A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy', Frontiers in Molecular Neuroscience, vol. 10, 447. https://doi.org/10.3389/fnmol.2017.00447en
dc.identifier.doi10.3389/fnmol.2017.00447
dc.identifier.issn1662-5099
dc.identifier.otherPubMedCentral: PMC5767730
dc.identifier.otherORCID: /0000-0002-5261-5467/work/73579148
dc.identifier.otherORCID: /0000-0001-7063-7136/work/96652493
dc.identifier.otherORCID: /0000-0003-2250-3920/work/47672902
dc.identifier.urihttp://hdl.handle.net/2164/9976
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofFrontiers in Molecular Neuroscienceen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectaggregation inhibitoren
dc.subjectsynucleinopathyen
dc.subjectleucomethylthioniniumen
dc.subjectmouse modelen
dc.subjectParkinson’s diseaseen
dc.subjectα-Synucleinen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathyen
dc.typeJournal articleen

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