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Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease

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dc.contributor.authorKoss, David J.
dc.contributor.authorDubini, Marina
dc.contributor.authorBuchanan, Heather
dc.contributor.authorHull, Claire
dc.contributor.authorPlatt, Bettina
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2019-08-09T23:06:00Z
dc.date.available2019-08-09T23:06:00Z
dc.date.embargoedUntil2019-08-10
dc.date.issued2018-11-15
dc.descriptionAcknowledgements We would like to deeply thank all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the Alzheimer’s Society and the Medical Research Council, and sourced from the MRC London Neurodegenerative Diseases Brain Bank, the Manchester Brain Bank, the South West Dementia Brain Bank (SWDBB), the Newcastle Brain Tissue Resource and the Oxford Brain Bank. The Newcastle Brain Tissue Resource and Oxford Brain Bank are also supported by the National Institute for Health Research (NIHR) Units. The South West Dementia Brain Bank (SWDBB) receives additional support from BRACE (Bristol Research into Alzheimer's and Care of the Elderly). Antibodies CP13 and PHF1 were generously provided by Prof Peter Davies. TOC1 antibodies were a gift from Nicholas Kanaan at Michigan State University (originally created by Lester Binder at Northwestern University). Funding The work presented here was funded by Alzheimer's Research UK (Grant refs: ARUK-PPG2014A-21, ARUK-NSG2015-1 and ARUK-NCG2017A-3 to BP and DK).en
dc.description.statusPeer revieweden
dc.format.extent14
dc.format.extent1472370
dc.identifier130868801
dc.identifier7232ffb9-370e-4445-b702-a2332bb7d41b
dc.identifier30102892
dc.identifier85051680368
dc.identifier000449126200013
dc.identifier.citationKoss, D J, Dubini, M, Buchanan, H, Hull, C & Platt, B 2018, 'Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease', Brain Research, vol. 1699, pp. 121-134. https://doi.org/10.1016/j.brainres.2018.08.014en
dc.identifier.doi10.1016/j.brainres.2018.08.014
dc.identifier.issn0006-8993
dc.identifier.otherORCID: /0000-0002-7852-0749/work/76976904
dc.identifier.urihttp://hdl.handle.net/2164/12708
dc.language.isoeng
dc.relation.ispartofBrain Researchen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAlzheimer’s diseaseen
dc.subjectTauen
dc.subjectβ-amyloiden
dc.subjectPathologyen
dc.subjectAggregationen
dc.subjectR Medicine (General)en
dc.subjectAlzheimers Research UKen
dc.subjectARUK-PPG2014A-21en
dc.subjectARUK-NSG2015-1en
dc.subjectARUK-NCG2017A-3en
dc.subject.lccR1en
dc.titleDistinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s diseaseen
dc.typeJournal articleen

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