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Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19 : a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial

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dc.contributor.authorKeir, Holly R
dc.contributor.authorLong, Merete B
dc.contributor.authorAbo-Leyah, Hani
dc.contributor.authorGiam, Yan Hui
dc.contributor.authorVadiveloo, Thenmalar
dc.contributor.authorPembridge, Thomas
dc.contributor.authorHull, Rebecca C
dc.contributor.authorDelgado, Lilia
dc.contributor.authorBand, Margaret
dc.contributor.authorMcLaren-Neil, Fiona
dc.contributor.authorAdamson, Simon
dc.contributor.authorLahnsteiner, Eva
dc.contributor.authorGilmour, Amy
dc.contributor.authorHughes, Chloe
dc.contributor.authorNew, Benjamin Jm
dc.contributor.authorConnell, David
dc.contributor.authorDowey, Rebecca
dc.contributor.authorTurton, Helena
dc.contributor.authorRichardson, Hollian
dc.contributor.authorCassidy, Diane
dc.contributor.authorCooper, Jamie
dc.contributor.authorSuntharalingam, Jay
dc.contributor.authorDiwakar, Lavanya
dc.contributor.authorRussell, Peter
dc.contributor.authorUnderwood, Jonathan
dc.contributor.authorHicks, Alexander
dc.contributor.authorDosanjh, Davinder Ps
dc.contributor.authorSage, Beth
dc.contributor.authorDhasmana, Devesh
dc.contributor.authorSpears, Mark
dc.contributor.authorThompson, AA Roger
dc.contributor.authorBrightling, Christopher
dc.contributor.authorSmith, Andrew
dc.contributor.authorPatel, Manish
dc.contributor.authorGeorge, Jacob
dc.contributor.authorCondliffe, Alison M
dc.contributor.authorShoemark, Amelia
dc.contributor.authorMacLennan, Graeme
dc.contributor.authorChalmers, James D
dc.contributor.authorSTOP-COVID19 Investigators
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Centre for Healthcare Randomised Trials (CHaRT)en
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2023-02-15T14:29:01Z
dc.date.available2023-02-15T14:29:01Z
dc.date.issued2022-12-01
dc.descriptionAcknowledgments This study was funded by an investigator-initiated research grant from Insmed (Bridgewater, NJ, USA). The authors acknowledge Stephen Senn (Edinburgh, UK) for independent statistical advice and Alex McConnachie (University of Glasgow, Glasgow, UK), Aran Singanayagam (Imperial College, London, UK), Oriol Sibila (Hospital Clínic Barcelona, Barcelona, Spain), and Petra Rauchhaus (University of Dundee, Dundee, UK) for serving as the independent data monitoring committee. The STOP-COVID19 study was designated an urgent public health priority study by the UK National Institute for Health and Care Research. The authors acknowledge the funding and logistical support from the UK National Institute for Health and Care Research.en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent981900
dc.identifier223831899
dc.identifierca8f23e5-2323-493a-b33a-13c854327571
dc.identifier85142783776
dc.identifier36075243
dc.identifier.citationKeir, H R, Long, M B, Abo-Leyah, H, Giam, Y H, Vadiveloo, T, Pembridge, T, Hull, R C, Delgado, L, Band, M, McLaren-Neil, F, Adamson, S, Lahnsteiner, E, Gilmour, A, Hughes, C, New, B J, Connell, D, Dowey, R, Turton, H, Richardson, H, Cassidy, D, Cooper, J, Suntharalingam, J, Diwakar, L, Russell, P, Underwood, J, Hicks, A, Dosanjh, D P, Sage, B, Dhasmana, D, Spears, M, Thompson, AA R, Brightling, C, Smith, A, Patel, M, George, J, Condliffe, A M, Shoemark, A, MacLennan, G, Chalmers, J D & STOP-COVID19 Investigators 2022, 'Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19 : a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial', The Lancet. Respiratory medicine, vol. 10, no. 12, pp. 1119-1128. https://doi.org/10.1016/S2213-2600(22)00261-2en
dc.identifier.doi10.1016/S2213-2600(22)00261-2
dc.identifier.issn2213-2600
dc.identifier.otherPubMedCentral: PMC9442496
dc.identifier.otherORCID: /0000-0002-1039-5646/work/188766253
dc.identifier.otherORCID: /0000-0003-3812-7026/work/188766569
dc.identifier.urihttps://hdl.handle.net/2164/20056
dc.identifier.urlhttps://www.scopus.com/pages/publications/85142783776en
dc.language.isoeng
dc.relation.ispartofThe Lancet. Respiratory medicineen
dc.subjectHumansen
dc.subjectCOVID-19 Drug Treatmenten
dc.subjectDouble-Blind Methoden
dc.subjectSerine Proteasesen
dc.subjectTreatment Outcomeen
dc.subjectCathepsin C/antagonists & inhibitorsen
dc.subjectR Medicine (General)en
dc.subjectPulmonary and Respiratory Medicineen
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subjectSupplementary Informationen
dc.subject.lccR1en
dc.titleDipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19 : a multicentre, double-blind, randomised, parallel-group, placebo-controlled trialen
dc.typeJournal articleen

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