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Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis : The BiCARB randomised controlled trial

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dc.contributor.authorWitham, Miles D.
dc.contributor.authorBand, Margaret
dc.contributor.authorChong, Huey Yi
dc.contributor.authorDonnan, Peter T.
dc.contributor.authorHampson, Greeta
dc.contributor.authorHu, May Khei
dc.contributor.authorLittleford, Roberta
dc.contributor.authorLamb, Edmund
dc.contributor.authorKalra, Philip
dc.contributor.authorKennedy, Gwen
dc.contributor.authorMcNamee, Paul
dc.contributor.authorPlews, Deirdre
dc.contributor.authorRauchhaus, Petra
dc.contributor.authorSoiza, Roy L.
dc.contributor.authorSumukadas, Deepa
dc.contributor.authorWarwick, Graham
dc.contributor.authorAvenell, Alison
dc.contributor.institutionUniversity of Aberdeen.Health Economics Research Uniten
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2024-04-10T14:51:01Z
dc.date.available2024-04-10T14:51:01Z
dc.date.issued2020-04
dc.descriptionFUNDING The BiCARB trial was funded by the National Institute for Health Research Health Technology Assessment programme (project reference 10/71/01). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The funder of the study had input into the study design via the original commissioning call specification. The funder had no other role in the study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit. Disclaimer: The Health Services Research Unit and Health Economics Research Unit are core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorate. Acknowledgements We acknowledge the support received via the NHS Scotland Support for Science scheme; the NIHR Renal and Ageing Comprehensive Research Networks; and the work of all of the research nurses, local investigators and study teams at sites; Tayside Clinical Trials Unit staff; and most importantly all those with kidney disease who participated in the trial. Professor Witham acknowledges support from the NIHR Newcastle Biomedical Research Centre. In addition, we acknowledge the support and advice we received from the independent Trial Steering Committee members (Professor David Stott, Professor Patrick Mark, Professor Tahir Masud and Mr. Alex Stephen) and the independent Data Monitoring Committee (Professor Alex McConnachie, Professor David Wheeler, Dr. Nicosha de Souza, Professor Andrew Clegg). We also acknowledge the efforts of all the investigators, site research nurses and support teams.en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent1881060
dc.identifier147649400
dc.identifier54b250c7-db63-4c47-902c-eaf9fc0803ad
dc.identifier.citationWitham, M D, Band, M, Chong, H Y, Donnan, P T, Hampson, G, Hu, M K, Littleford, R, Lamb, E, Kalra, P, Kennedy, G, McNamee, P, Plews, D, Rauchhaus, P, Soiza, R L, Sumukadas, D, Warwick, G & Avenell, A 2020, 'Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis : The BiCARB randomised controlled trial', Health Technology Assessment, vol. 18, 91. https://doi.org/10.1186/s12916-020-01542-9en
dc.identifier.doi10.1186/s12916-020-01542-9
dc.identifier.issn1366-5278
dc.identifier.otherORCID: /0000-0002-1397-4272/work/157655822
dc.identifier.otherORCID: /0000-0003-4813-5628/work/167120302
dc.identifier.urihttps://hdl.handle.net/2164/23215
dc.identifier.vol18en
dc.language.isoeng
dc.relation.ispartofHealth Technology Assessmenten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectsodium bicarbonateen
dc.subjectrenal insufficiencyen
dc.subjectchronicen
dc.subjectacidosisen
dc.subjectrandomised controlled trialen
dc.subjectR Medicine (General)en
dc.subjectNational Institute for Health Research (NIHR)en
dc.subject10/71/01en
dc.subjectSupplementary Informationen
dc.subjectSupplementary informationen
dc.subject.lccR1en
dc.titleClinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis : The BiCARB randomised controlled trialen
dc.typeJournal articleen

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