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Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy

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dc.contributor.authorLeow, Damien Meng-Kiat
dc.contributor.authorNg, Yang Kai
dc.contributor.authorWang, Loo Chien
dc.contributor.authorKoh, Hiromi Wl
dc.contributor.authorZhao, Tianyun
dc.contributor.authorKhong, Zi Jian
dc.contributor.authorTabaglio, Tommaso
dc.contributor.authorNarayanan, Gunaseelan
dc.contributor.authorGiadone, Richard M
dc.contributor.authorSobota, Radoslaw M
dc.contributor.authorNg, Shi-Yan
dc.contributor.authorTeo, Adrian Kk
dc.contributor.authorParson, Simon H
dc.contributor.authorRubin, Lee L
dc.contributor.authorOng, Wei-Yi
dc.contributor.authorDarras, Basil T
dc.contributor.authorYeo, Crystal Jj
dc.contributor.institutionUniversity of Aberdeen.Institute of Education in Healthcare and Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.The Suttie Centre - Anatomyen
dc.date.accessioned2024-07-19T23:17:14Z
dc.date.available2024-07-19T23:17:14Z
dc.date.issued2024-06-17
dc.descriptionThis work was supported by an Agency for Science, Technology and Research (A*STAR) CDF grant number C210112024 (to CJJY). Acknowledgments to Dave Wee, Edward Manser, Frederick Bard, and Uttam Surana from A*STAR for scientific discussions and to Shaye Moore from Boston Children’s Hospital for assistance with editing and submission.en
dc.description.statusPeer revieweden
dc.format.extent19
dc.format.extent14907309
dc.identifier289458089
dc.identifier82d7385d-184f-4295-8fd5-87a656cb4dfd
dc.identifier38722695
dc.identifier85196821178
dc.identifier.citationLeow, D M-K, Ng, Y K, Wang, L C, Koh, H W, Zhao, T, Khong, Z J, Tabaglio, T, Narayanan, G, Giadone, R M, Sobota, R M, Ng, S-Y, Teo, A K, Parson, S H, Rubin, L L, Ong, W-Y, Darras, B T & Yeo, C J 2024, 'Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy', The Journal of Clinical Investigation, vol. 134, no. 12, e173702. https://doi.org/10.1172/JCI173702en
dc.identifier.doi10.1172/JCI173702
dc.identifier.iss12en
dc.identifier.issn0021-9738
dc.identifier.otherORCID: /0000-0002-8848-8738/work/159510206
dc.identifier.urihttps://hdl.handle.net/2164/23868
dc.identifier.vol134en
dc.language.isoeng
dc.relation.ispartofThe Journal of Clinical Investigationen
dc.subjectR Medicineen
dc.subjectSupplementary Dataen
dc.subjecthttps://www.jci.org/articles/view/173702/sd/1en
dc.subjecthttps://www.jci.org/articles/view/173702/sd/2en
dc.subjecthttps://www.jci.org/articles/view/173702/sd/3en
dc.subjecthttps://www.jci.org/articles/view/173702#sden
dc.subject.lccRen
dc.titleHepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophyen
dc.typeJournal articleen

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