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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

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dc.contributor.authorLiew, Felicity
dc.contributor.authorEfstathiou, Claudia
dc.contributor.authorFontanella, Sara
dc.contributor.authorRichardson, Matthew
dc.contributor.authorSaunders, Ruth
dc.contributor.authorSwieboda, Dawid
dc.contributor.authorSidhu, Jasmin K.
dc.contributor.authorAscough, Stephanie
dc.contributor.authorMoore, Shona C.
dc.contributor.authorMohamed, Noura
dc.contributor.authorNunag, Jose
dc.contributor.authorKing, Clara
dc.contributor.authorLeavy, Olivia C.
dc.contributor.authorElneima, Omer
dc.contributor.authorMcAuley, Hamish J.C.
dc.contributor.authorShikotra, Aarti
dc.contributor.authorSingapuri, Amisha
dc.contributor.authorSereno, Marco
dc.contributor.authorHarris, Victoria C.
dc.contributor.authorHouchen-Wolloff, Linzy
dc.contributor.authorGreening, Neil J.
dc.contributor.authorLone, Nazir I.
dc.contributor.authorThorpe, Matthew
dc.contributor.authorThompson, A. A.Roger
dc.contributor.authorRowland-Jones, Sarah L.
dc.contributor.authorDocherty, Annemarie B.
dc.contributor.authorChalmers, James D.
dc.contributor.authorHo, Ling Pei
dc.contributor.authorHorsley, Alexander
dc.contributor.authorRaman, Betty
dc.contributor.authorPoinasamy, Krisnah
dc.contributor.authorMarks, Michael
dc.contributor.authorKon, Onn Min
dc.contributor.authorHoward, Luke S.
dc.contributor.authorWootton, Daniel G.
dc.contributor.authorQuint, Jennifer K.
dc.contributor.authorde Silva, Thushan I.
dc.contributor.authorHo, Antonia
dc.contributor.authorChiu, Christopher
dc.contributor.authorHarrison, Ewen M.
dc.contributor.authorGreenhalf, William
dc.contributor.authorBaillie, J. Kenneth
dc.contributor.authorSemple, Malcolm G.
dc.contributor.authorTurtle, Lance
dc.contributor.authorEvans, Rachael A.
dc.contributor.authorWain, Louise V.
dc.contributor.authorBrightling, Christopher
dc.contributor.authorThwaites, Ryan S.
dc.contributor.authorOpenshaw, Peter J. M.
dc.contributor.authorPHOSP-COVID collaborative group
dc.contributor.authorISARIC investigators
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2024-08-30T11:34:01Z
dc.date.available2024-08-30T11:34:01Z
dc.date.issued2024-04-08
dc.descriptionWe thank all the participants and their families. We thank the many research administrators, health-care and social-care professionals who contributed to setting up and delivering the PHOSP-COVID study at all of the 65 NHS trusts/health boards and 25 research institutions across the United Kingdom, as well as those who contributed to setting up and delivering the ISARIC4C study at 305 NHS trusts/health boards. We also thank all the supporting staff at the NIHR Clinical Research Network, Health Research Authority, Research Ethics Committee, Department of Health and Social Care, Public Health Scotland and Public Health England. We thank K. Holmes at the NIHR Office for Clinical Research Infrastructure for her support in coordinating the charities group. The PHOSP-COVID industry framework was formed to provide advice and support in commercial discussions, and we thank the Association of the British Pharmaceutical Industry as well the NIHR Office for Clinical Research Infrastructure for coordinating this. We are very grateful to all the charities that have provided insight to the study: Action Pulmonary Fibrosis, Alzheimer\u2019s Research UK, Asthma and Lung UK, British Heart Foundation, Diabetes UK, Cystic Fibrosis Trust, Kidney Research UK, MQ Mental Health, Muscular Dystrophy UK, Stroke Association Blood Cancer UK, McPin Foundations and Versus Arthritis. We thank the NIHR Leicester Biomedical Research Centre patient and public involvement group and Long Covid Support. We also thank G. Khandaker and D. C. Newcomb who provided valuable feedback on this work. Extended Data Fig. was created using Biorender.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent15169287
dc.identifier292298991
dc.identifier640fa0fe-cd43-4ce2-b6b3-0734690eb79e
dc.identifier85190085946
dc.identifier38589621
dc.identifier.citationLiew, F, Efstathiou, C, Fontanella, S, Richardson, M, Saunders, R, Swieboda, D, Sidhu, J K, Ascough, S, Moore, S C, Mohamed, N, Nunag, J, King, C, Leavy, O C, Elneima, O, McAuley, H J C, Shikotra, A, Singapuri, A, Sereno, M, Harris, V C, Houchen-Wolloff, L, Greening, N J, Lone, N I, Thorpe, M, Thompson, A A R, Rowland-Jones, S L, Docherty, A B, Chalmers, J D, Ho, L P, Horsley, A, Raman, B, Poinasamy, K, Marks, M, Kon, O M, Howard, L S, Wootton, D G, Quint, J K, de Silva, T I, Ho, A, Chiu, C, Harrison, E M, Greenhalf, W, Baillie, J K, Semple, M G, Turtle, L, Evans, R A, Wain, L V, Brightling, C, Thwaites, R S, Openshaw, P J M, PHOSP-COVID collaborative group & ISARIC investigators 2024, 'Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease', Nature Immunology, vol. 25, no. 4, pp. 607-621. https://doi.org/10.1038/s41590-024-01778-0en
dc.identifier.doi10.1038/s41590-024-01778-0
dc.identifier.iss4en
dc.identifier.issn1529-2908
dc.identifier.otherORCID: /0000-0003-1336-7744/work/166663554
dc.identifier.urihttps://hdl.handle.net/2164/24138
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85190085946&partnerID=8YFLogxKen
dc.identifier.vol25en
dc.language.isoeng
dc.relation.ispartofNature Immunologyen
dc.subjectR Medicine (General)en
dc.subjectImmunology and Allergyen
dc.subjectImmunologyen
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subjectSupplementary Informationen
dc.subject.lccR1en
dc.titleLarge-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of diseaseen
dc.typeJournal itemen

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