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Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

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dc.contributor.authorKang, Eunchai
dc.contributor.authorJiang, Danye
dc.contributor.authorRyu, Yun Kyoung
dc.contributor.authorLim, Sanghee
dc.contributor.authorKwak, Minhye
dc.contributor.authorGray, Christy D.
dc.contributor.authorXu, Michael
dc.contributor.authorChoi, Jun H.
dc.contributor.authorJunn, Sue
dc.contributor.authorKim, Jieun
dc.contributor.authorXu, Jing
dc.contributor.authorSchaefer, Michele
dc.contributor.authorJohns, Roger A.
dc.contributor.authorSong, Hongjun
dc.contributor.authorMing, Guo Li
dc.contributor.authorMintz, C. David
dc.date.accessioned2020-09-02T09:15:01Z
dc.date.available2020-09-02T09:15:01Z
dc.date.issued2017-07-06
dc.descriptionFunding: Johns Hopkins ACCM Department anesthesiology.hopkinsmedicine.org (grant number StAAR) to CDM. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH-NIGMS www.nih.gov (grant number 1R01GM120519-01 and 1K08GM104329-01) to CDM. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH www.nih.gov (grant number NS048271 and MH105128) to GLM. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH www.nih.gov (grant number NS047344) to HS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments: We would like to acknowledge the helpful contributions of Sunu Kim (technical assistance) and Allan Gottschalk (critical commentary).en
dc.description.statusPeer revieweden
dc.format.extent18
dc.format.extent7701026
dc.identifier163812162
dc.identifier565e53c8-8f6b-45af-a621-e151aa16418c
dc.identifier85026746864
dc.identifier28683067
dc.identifier.citationKang, E, Jiang, D, Ryu, Y K, Lim, S, Kwak, M, Gray, C D, Xu, M, Choi, J H, Junn, S, Kim, J, Xu, J, Schaefer, M, Johns, R A, Song, H, Ming, G L & Mintz, C D 2017, 'Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway', PLoS Biology, vol. 15, no. 7, e2001246. https://doi.org/10.1371/journal.pbio.2001246en
dc.identifier.doi10.1371/journal.pbio.2001246
dc.identifier.iss7en
dc.identifier.issn1544-9173
dc.identifier.otherORCID: /0000-0001-6884-622X/work/79765639
dc.identifier.urihttps://hdl.handle.net/2164/15059
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85026746864&partnerID=8YFLogxKen
dc.identifier.vol15en
dc.language.isoeng
dc.relation.ispartofPLoS Biologyen
dc.subjectQH301 Biologyen
dc.subjectGeneral Neuroscienceen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectGeneral Immunology and Microbiologyen
dc.subjectGeneral Agricultural and Biological Sciencesen
dc.subjectSupplementary Dataen
dc.subject.lccQH301en
dc.titleEarly postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathwayen
dc.typeJournal articleen

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