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Sequential enhancer state remodelling defines human germline competence and specification

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dc.contributor.authorTang, Walfred W C
dc.contributor.authorCastillo-Venzor, Aracely
dc.contributor.authorGruhn, Wolfram H
dc.contributor.authorKobayashi, Toshihiro
dc.contributor.authorPenfold, Christopher A
dc.contributor.authorMorgan, Michael D
dc.contributor.authorSun, Dawei
dc.contributor.authorIrie, Naoko
dc.contributor.authorSurani, M Azim
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2023-04-24T11:45:01Z
dc.date.available2023-04-24T11:45:01Z
dc.date.embargoedUntil2022-08-28
dc.date.issued2022-04-11
dc.descriptionAcknowledgements M.A.S. was supported by Wellcome Investigator Awards in Science (209475/Z/17/Z and 096738/Z/11/Z), an MRC research grant (RG85305) and a BBSRC research grant (G103986). W.W.C.T. received a Croucher Postdoctoral Research Fellowship and was supported by the Isaac Newton Trust. A.C.-V. was supported by the Wellcome 4-Year PhD Programme in Stem Cell Biology and Medicine and the Cambridge Commonwealth European and International Trust (203831/Z/16/Z). W.H.G. was supported by a BBSRC research grant (G103986). T.K. and M.A.S. were supported by Butterfield Awards of Great Britain Sasakawa Foundation. T.K. was supported by the Astellas Foundation for Research on Metabolic Disorders. D.S. was supported by a Wellcome Trust PhD studentship (109146/Z/15/Z) and the Department of Pathology, University of Cambridge. N.I. was supported by an MRC research grant (RG85305). We thank R. Barker and X. He for providing human embryonic tissues, and C. Bradshaw for bioinformatic support. We also thank The Weizmann Institute of Science for the WIS2 hESC line and the Genomics Core Facility of CRUK Cambridge Institute for sequencing services, and R. Alberio and members of the Surani lab for insightful comments and critical reading of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent47486705
dc.identifier221553608
dc.identifier04c18596-5be5-4e9e-ab27-d7169e19cc05
dc.identifier35411086
dc.identifier85128065234
dc.identifier.citationTang, W W C, Castillo-Venzor, A, Gruhn, W H, Kobayashi, T, Penfold, C A, Morgan, M D, Sun, D, Irie, N & Surani, M A 2022, 'Sequential enhancer state remodelling defines human germline competence and specification', Nature Cell Biology, vol. 24, no. 4, pp. 448-460. https://doi.org/10.1038/s41556-022-00878-zen
dc.identifier.doi10.1038/s41556-022-00878-z
dc.identifier.iss4en
dc.identifier.issn1465-7392
dc.identifier.otherPubMedCentral: PMC7612729
dc.identifier.otherORCID: /0000-0003-0757-0711/work/133803885
dc.identifier.urihttps://hdl.handle.net/2164/20542
dc.identifier.urlhttps://www.repository.cam.ac.uk/handle/1810/334690en
dc.identifier.vol24en
dc.language.isoeng
dc.relation.ispartofNature Cell Biologyen
dc.subjectAnimalsen
dc.subjectCell Differentiation/geneticsen
dc.subjectEmbryonic Development/geneticsen
dc.subjectEndodermen
dc.subjectGastrulationen
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectGerm Cells/metabolismen
dc.subjectHumansen
dc.subjectMammalsen
dc.subjectQH426 Geneticsen
dc.subjectWellcome Trusten
dc.subject209475/Z/17/Zen
dc.subject096738/Z/11/Zen
dc.subject203831/Z/16/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectRG85305en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectG103986en
dc.subjectSupplementary Dataen
dc.subject.lccQH426en
dc.titleSequential enhancer state remodelling defines human germline competence and specificationen
dc.typeJournal articleen

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