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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

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dc.contributor.authorNtalla, Ioanna
dc.contributor.authorWeng, Lu-Chen
dc.contributor.authorCartwright, James H
dc.contributor.authorHall, Amelia Weber
dc.contributor.authorSveinbjornsson, Gardar
dc.contributor.authorTucker, Nathan R
dc.contributor.authorChoi, Seung Hoan
dc.contributor.authorChaffin, Mark D
dc.contributor.authorRoselli, Carolina
dc.contributor.authorBarnes, Michael R
dc.contributor.authorMifsud, Borbala
dc.contributor.authorWarren, Helen R
dc.contributor.authorHayward, Caroline
dc.contributor.authorMarten, Jonathan
dc.contributor.authorCranley, James J
dc.contributor.authorConcas, Maria Pina
dc.contributor.authorGasparini, Paolo
dc.contributor.authorBoutin, Thibaud
dc.contributor.authorKolcic, Ivana
dc.contributor.authorPolasek, Ozren
dc.contributor.authorRudan, Igor
dc.contributor.authorAraujo, Nathalia M
dc.contributor.authorLima-Costa, Maria Fernanda
dc.contributor.authorRibeiro, Antonio Luiz P
dc.contributor.authorSouza, Renan P
dc.contributor.authorTarazona-Santos, Eduardo
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorIngelsson, Erik
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMorris, Andrew P
dc.contributor.authorDel Greco M, Fabiola
dc.contributor.authorFoco, Luisa
dc.contributor.authorGögele, Martin
dc.contributor.authorHicks, Andrew A
dc.contributor.authorCook, James P
dc.contributor.authorLind, Lars
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorSundström, Johan
dc.contributor.authorNelson, Christopher P
dc.contributor.authorRiaz, Muhammad B
dc.contributor.authorSamani, Nilesh J
dc.contributor.authorSinagra, Gianfranco
dc.contributor.authorUlivi, Sheila
dc.contributor.authorKähönen, Mika
dc.contributor.authorMishra, Pashupati P
dc.contributor.authorMononen, Nina
dc.contributor.authorNikus, Kjell
dc.contributor.authorCaulfield, Mark J
dc.contributor.authorDominiczak, Anna
dc.contributor.authorPadmanabhan, Sandosh
dc.contributor.authorMontasser, May E
dc.contributor.authorO'Connell, Jeff R
dc.contributor.authorRyan, Kathleen
dc.contributor.authorShuldiner, Alan R
dc.contributor.authorAeschbacher, Stefanie
dc.contributor.authorConen, David
dc.contributor.authorRisch, Lorenz
dc.contributor.authorThériault, Sébastien
dc.contributor.authorHutri-Kähönen, Nina
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorRaitakari, Olli T
dc.contributor.authorBarnes, Catriona L K
dc.contributor.authorCampbell, Harry
dc.contributor.authorJoshi, Peter K
dc.contributor.authorWilson, James F
dc.contributor.authorIsaacs, Aaron
dc.contributor.authorKors, Jan A
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorHuang, Paul L
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B
dc.contributor.authorLauner, Lenore J
dc.contributor.authorSmith, Albert V
dc.contributor.authorBottinger, Erwin P
dc.contributor.authorLoos, Ruth J F
dc.contributor.authorNadkarni, Girish N
dc.contributor.authorPreuss, Michael H
dc.contributor.authorCorrea, Adolfo
dc.contributor.authorMei, Hao
dc.contributor.authorWilson, James
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorPeters, Annette
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorMangino, Massimo
dc.contributor.authorSpector, Timothy D
dc.contributor.authorRienstra, Michiel
dc.contributor.authorvan de Vegte, Yordi J
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorVerweij, Niek
dc.contributor.authorKääb, Stefan
dc.contributor.authorSchramm, Katharina
dc.contributor.authorSinner, Moritz F
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorCutler, Michael J
dc.contributor.authorFatkin, Diane
dc.contributor.authorLondon, Barry
dc.contributor.authorOlesen, Morten
dc.contributor.authorRoden, Dan M
dc.contributor.authorBenjamin Shoemaker, M
dc.contributor.authorGustav Smith, J
dc.contributor.authorBiggs, Mary L
dc.contributor.authorBis, Joshua C
dc.contributor.authorBrody, Jennifer A
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRice, Kenneth
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorDe Grandi, Alessandro
dc.contributor.authorFuchsberger, Christian
dc.contributor.authorPattaro, Cristian
dc.contributor.authorPramstaller, Peter P
dc.contributor.authorFord, Ian
dc.contributor.authorWouter Jukema, J
dc.contributor.authorMacfarlane, Peter W
dc.contributor.authorTrompet, Stella
dc.contributor.authorDörr, Marcus
dc.contributor.authorFelix, Stephan B
dc.contributor.authorVölker, Uwe
dc.contributor.authorWeiss, Stefan
dc.contributor.authorHavulinna, Aki S
dc.contributor.authorJula, Antti
dc.contributor.authorSääksjärvi, Katri
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorHeckbert, Susan R
dc.contributor.authorLin, Henry J
dc.contributor.authorRotter, Jerome I
dc.contributor.authorTaylor, Kent D
dc.contributor.authorYao, Jie
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorMaan, Arie C
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorNoordam, Raymond
dc.contributor.authorCucca, Francesco
dc.contributor.authorDing, Jun
dc.contributor.authorLakatta, Edward G
dc.contributor.authorQian, Yong
dc.contributor.authorTarasov, Kirill V
dc.contributor.authorLevy, Daniel
dc.contributor.authorLin, Honghuang
dc.contributor.authorNewton-Cheh, Christopher H
dc.contributor.authorLunetta, Kathryn L
dc.contributor.authorMurray, Alison D
dc.contributor.authorPorteous, David J
dc.contributor.authorSmith, Blair H
dc.contributor.authorStricker, Bruno H
dc.contributor.authorUitterlinden, André
dc.contributor.authorvan den Berg, Marten E
dc.contributor.authorHaessler, Jeffrey
dc.contributor.authorJackson, Rebecca D
dc.contributor.authorKooperberg, Charles
dc.contributor.authorPeters, Ulrike
dc.contributor.authorReiner, Alexander P
dc.contributor.authorWhitsel, Eric A
dc.contributor.authorAlonso, Alvaro
dc.contributor.authorArking, Dan E
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorEhret, Georg B
dc.contributor.authorSoliman, Elsayed Z
dc.contributor.authorAvery, Christy L
dc.contributor.authorGogarten, Stephanie M
dc.contributor.authorKerr, Kathleen F
dc.contributor.authorLaurie, Cathy C
dc.contributor.authorSeyerle, Amanda A
dc.contributor.authorStilp, Adrienne
dc.contributor.authorAssa, Solmaz
dc.contributor.authorAbdullah Said, M
dc.contributor.authorYldau van der Ende, M
dc.contributor.authorLambiase, Pier D
dc.contributor.authorOrini, Michele
dc.contributor.authorRamirez, Julia
dc.contributor.authorVan Duijvenboden, Stefan
dc.contributor.authorArnar, David O
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorHolm, Hilma
dc.contributor.authorSulem, Patrick
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorThorolfsdottir, Rosa B
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorBenjamin, Emelia J
dc.contributor.authorTinker, Andrew
dc.contributor.authorStefansson, Kari
dc.contributor.authorEllinor, Patrick T
dc.contributor.authorJamshidi, Yalda
dc.contributor.authorLubitz, Steven A
dc.contributor.authorMunroe, Patricia B
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.date.accessioned2020-06-29T16:40:01Z
dc.date.available2020-06-29T16:40:01Z
dc.date.issued2020-05-21
dc.descriptionAcknowledgements We provide all investigator and study-specific acknowledgements in Supplementary Note 1, and funding sources in Supplementary Note 2.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent3546179
dc.identifier159502023
dc.identifierdaee48ed-8897-47c2-b7fd-70b73e2944ad
dc.identifier32439900
dc.identifier32439900
dc.identifier85085157192
dc.identifier000537067700001
dc.identifier.citationNtalla, I, Weng, L-C, Cartwright, J H, Hall, A W, Sveinbjornsson, G, Tucker, N R, Choi, S H, Chaffin, M D, Roselli, C, Barnes, M R, Mifsud, B, Warren, H R, Hayward, C, Marten, J, Cranley, J J, Concas, M P, Gasparini, P, Boutin, T, Kolcic, I, Polasek, O, Rudan, I, Araujo, N M, Lima-Costa, M F, Ribeiro, A L P, Souza, R P, Tarazona-Santos, E, Giedraitis, V, Ingelsson, E, Mahajan, A, Morris, A P, Del Greco M, F, Foco, L, Gögele, M, Hicks, A A, Cook, J P, Lind, L, Lindgren, C M, Sundström, J, Nelson, C P, Riaz, M B, Samani, N J, Sinagra, G, Ulivi, S, Kähönen, M, Mishra, P P, Mononen, N, Nikus, K, Caulfield, M J, Dominiczak, A, Padmanabhan, S, Montasser, M E, O'Connell, J R, Ryan, K, Shuldiner, A R, Aeschbacher, S, Conen, D, Risch, L, Thériault, S, Hutri-Kähönen, N, Lehtimäki, T, Lyytikäinen, L-P, Raitakari, O T, Barnes, C L K, Campbell, H, Joshi, P K, Wilson, J F, Isaacs, A, Kors, J A, van Duijn, C M, Huang, P L, Gudnason, V, Harris, T B, Launer, L J, Smith, A V, Bottinger, E P, Loos, R J F, Nadkarni, G N, Preuss, M H, Correa, A, Mei, H, Wilson, J, Meitinger, T, Müller-Nurasyid, M, Peters, A, Waldenberger, M, Mangino, M, Spector, T D, Rienstra, M, van de Vegte, Y J, van der Harst, P, Verweij, N, Kääb, S, Schramm, K, Sinner, M F, Strauch, K, Cutler, M J, Fatkin, D, London, B, Olesen, M, Roden, D M, Benjamin Shoemaker, M, Gustav Smith, J, Biggs, M L, Bis, J C, Brody, J A, Psaty, B M, Rice, K, Sotoodehnia, N, De Grandi, A, Fuchsberger, C, Pattaro, C, Pramstaller, P P, Ford, I, Wouter Jukema, J, Macfarlane, P W, Trompet, S, Dörr, M, Felix, S B, Völker, U, Weiss, S, Havulinna, A S, Jula, A, Sääksjärvi, K, Salomaa, V, Guo, X, Heckbert, S R, Lin, H J, Rotter, J I, Taylor, K D, Yao, J, de Mutsert, R, Maan, A C, Mook-Kanamori, D O, Noordam, R, Cucca, F, Ding, J, Lakatta, E G, Qian, Y, Tarasov, K V, Levy, D, Lin, H, Newton-Cheh, C H, Lunetta, K L, Murray, A D, Porteous, D J, Smith, B H, Stricker, B H, Uitterlinden, A, van den Berg, M E, Haessler, J, Jackson, R D, Kooperberg, C, Peters, U, Reiner, A P, Whitsel, E A, Alonso, A, Arking, D E, Boerwinkle, E, Ehret, G B, Soliman, E Z, Avery, C L, Gogarten, S M, Kerr, K F, Laurie, C C, Seyerle, A A, Stilp, A, Assa, S, Abdullah Said, M, Yldau van der Ende, M, Lambiase, P D, Orini, M, Ramirez, J, Van Duijvenboden, S, Arnar, D O, Gudbjartsson, D F, Holm, H, Sulem, P, Thorleifsson, G, Thorolfsdottir, R B, Thorsteinsdottir, U, Benjamin, E J, Tinker, A, Stefansson, K, Ellinor, P T, Jamshidi, Y, Lubitz, S A & Munroe, P B 2020, 'Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction', Nature Communications, vol. 11, 2542. https://doi.org/10.1038/s41467-020-15706-xen
dc.identifier.doi10.1038/s41467-020-15706-x
dc.identifier.issn2041-1723
dc.identifier.otherPubMedCentral: PMC7242331
dc.identifier.urihttps://hdl.handle.net/2164/14604
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85085157192&partnerID=8YFLogxKen
dc.identifier.vol11en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectcardiovascular diseasesen
dc.subjectcardiovascular geneticsen
dc.subjectgenome-wide association studiesen
dc.subjectCARDIOMYOPATHYen
dc.subjectDECREASEen
dc.subjectRISKen
dc.subjectBRADYCARDIAen
dc.subjectATRIAL-FIBRILLATIONen
dc.subjectELEMENTSen
dc.subjectCALCINEURINen
dc.subjectMUTATIONSen
dc.subjectDURATIONen
dc.subjectGENOME-WIDE ASSOCIATIONen
dc.subjectR Medicineen
dc.subjectGeneral Physics and Astronomyen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleMulti-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conductionen
dc.typeJournal articleen

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